| # | Title | Journal | Year | Citations |
|---|
| 1 | Statistical parametric maps in functional imaging: A general linear approach | Human Brain Mapping | 1994 | 8,177 |
| 2 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
| 3 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 4 | Metamaterials and Negative Refractive Index | Science | 2004 | 3,779 |
| 5 | Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase | Nature Medicine | 2002 | 3,692 |
| 6 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 7 | Microbial translocation is a cause of systemic immune activation in chronic HIV infection | Nature Medicine | 2006 | 3,107 |
| 8 | Second consensus statement on the diagnosis of multiple system atrophy | Neurology | 2008 | 2,720 |
| 9 | Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development | Cell | 1997 | 2,620 |
| 10 | ESMO consensus guidelines for the management of patients with metastatic colorectal cancer | Annals of Oncology | 2016 | 2,545 |
| 11 | AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism | Cell Metabolism | 2005 | 2,541 |
| 12 | The neural correlates of the verbal component of working memory | Nature | 1993 | 2,322 |
| 13 | Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 | Science | 2009 | 2,295 |
| 14 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 15 | Functional and effective connectivity in neuroimaging: A synthesis | Human Brain Mapping | 1994 | 1,964 |
| 16 | Ghrelin Enhances Appetite and Increases Food Intake in Humans | Journal of Clinical Endocrinology and Metabolism | 2001 | 1,866 |
| 17 | Simplified Reference Tissue Model for PET Receptor Studies | NeuroImage | 1996 | 1,864 |
| 18 | Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase | Nature | 2002 | 1,823 |
| 19 | Defining the role of common variation in the genomic and biological architecture of adult human height | Nature Genetics | 2014 | 1,818 |
| 20 | A role for glucagon-like peptide-1 in the central regulation of feeding | Nature | 1996 | 1,692 |
| 21 | Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets | Journal of Cerebral Blood Flow and Metabolism | 1993 | 1,688 |
| 22 | Assessing the significance of focal activations using their spatial extent | Human Brain Mapping | 1994 | 1,654 |
| 23 | Large recurrent microdeletions associated with schizophrenia | Nature | 2008 | 1,619 |
| 24 | Immunological Memory and Protective Immunity: Understanding Their Relation | Science | 1996 | 1,596 |
| 25 | Common variants conferring risk of schizophrenia | Nature | 2009 | 1,572 |
| 26 | Comparing Functional (PET) Images: The Assessment of Significant Change | Journal of Cerebral Blood Flow and Metabolism | 1991 | 1,553 |
| 27 | Measurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations | European Journal of Cancer | 1999 | 1,550 |
| 28 | Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification | Nature | 1990 | 1,522 |
| 29 | GLUCAGON-LIKE PEPTIDE-1 7-36: A PHYSIOLOGICAL INCRETIN IN MAN | Lancet, The | 1987 | 1,500 |
| 30 | Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide | Blood | 2003 | 1,483 |
| 31 | Explaining heterogeneity in meta-analysis: a comparison of methods | Blood | 1999 | 1,478 |
| 32 | Comparison of adjuvant gemcitabine and capecitabine with gemcitabine monotherapy in patients with resected pancreatic cancer (ESPAC-4): a multicentre, open-label, randomised, phase 3 trial | Lancet, The | 2017 | 1,475 |
| 33 | Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy | New England Journal of Medicine | 2009 | 1,471 |
| 34 | LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade | Current Biology | 2003 | 1,456 |
| 35 | Large-scale association analysis identifies new risk loci for coronary artery disease | Nature Genetics | 2013 | 1,439 |
| 36 | Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome) | Nature Genetics | 2000 | 1,391 |
| 37 | Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. | Journal of Clinical Investigation | 1989 | 1,390 |
| 38 | The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion | Endocrinology | 2000 | 1,370 |
| 39 | New genetic loci link adipose and insulin biology to body fat distribution | Nature | 2015 | 1,328 |
| 40 | MORTALITY AND MORBIDITY RESULTS FROM THE EUROPEAN WORKING PARTY ON HIGH BLOOD PRESSURE IN THE ELDERLY TRIAL*1, *2 | Lancet, The | 1985 | 1,321 |
| 41 | Pre-metastatic niches: organ-specific homes for metastases | Nature Reviews Cancer | 2017 | 1,272 |
| 42 | ANTICARDIOLIPIN ANTIBODIES: DETECTION BY RADIOIMMUNOASSAY AND ASSOCIATION WITH THROMBOSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS | Lancet, The | 1983 | 1,254 |
| 43 | Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy | Nature Genetics | 1999 | 1,245 |
| 44 | Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease | Nature Medicine | 2003 | 1,244 |
| 45 | The catalase—peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis | Nature | 1992 | 1,243 |
| 46 | Common variants at 30 loci contribute to polygenic dyslipidemia | Nature Genetics | 2009 | 1,234 |
| 47 | Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity | Science | 1995 | 1,221 |
| 48 | Stem Cell Function, Self-Renewal, and Behavioral Heterogeneity of Cells from the Adult Muscle Satellite Cell Niche | Cell | 2005 | 1,221 |
| 49 | What do we mean by validating a prognostic model? | Cell | 2000 | 1,216 |
| 50 | Chromatin signatures of pluripotent cell lines | Nature Cell Biology | 2006 | 1,213 |
