| # | Title | Journal | Year | Citations |
|---|
| 1 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 2 | Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases | Journals of Gerontology - Series A Biological Sciences and Medical Sciences | 2014 | 2,606 |
| 3 | An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics | Cell | 2018 | 2,277 |
| 4 | Chronic inflammation in the etiology of disease across the life span | Nature Medicine | 2019 | 2,195 |
| 5 | Aging, Cellular Senescence, and Cancer | Annual Review of Physiology | 2013 | 2,124 |
| 6 | Assessing mitochondrial dysfunction in cells | Biochemical Journal | 2011 | 1,949 |
| 7 | Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion | Nature Cell Biology | 2009 | 1,734 |
| 8 | Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer | Cell | 2018 | 1,718 |
| 9 | Geroscience: Linking Aging to Chronic Disease | Cell | 2014 | 1,709 |
| 10 | Lack of Exercise Is a Major Cause of Chronic Diseases | | 2012 | 1,673 |
| 11 | Oxidative stress in neurodegeneration: cause or consequence? | Nature Medicine | 2004 | 1,562 |
| 12 | Cellular Senescence: Defining a Path Forward | Cell | 2019 | 1,551 |
| 13 | Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer | Cell | 2015 | 1,485 |
| 14 | An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA | Developmental Cell | 2014 | 1,376 |
| 15 | Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo | Proceedings of the National Academy of Sciences of the United States of America | 2002 | 1,368 |
| 16 | Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice | Nature Medicine | 2016 | 1,273 |
| 17 | Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin | Cell | 2014 | 1,242 |
| 18 | Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo | Nature Protocols | 2009 | 1,234 |
| 19 | Reversal of human cellular senescence: roles of the p53 and p16 pathways | EMBO Journal | 2003 | 1,131 |
| 20 | Inflammatory networks during cellular senescence: causes and consequences | Trends in Molecular Medicine | 2010 | 1,052 |
| 21 | Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | Nature Cell Biology | 2003 | 1,003 |
| 22 | Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat | Proceedings of the National Academy of Sciences of the United States of America | 2001 | 1,000 |
| 23 | Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment | Nature Medicine | 2017 | 994 |
| 24 | Multi-site assessment of the precision and reproducibility of multiple reaction monitoring–based measurements of proteins in plasma | Nature Biotechnology | 2009 | 958 |
| 25 | The sites and topology of mitochondrial superoxide production | Experimental Gerontology | 2010 | 954 |
| 26 | Increased hippocampal neurogenesis in Alzheimer's disease | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 932 |
| 27 | Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse | Cancer Discovery | 2017 | 881 |
| 28 | Coupling endoplasmic reticulum stress to the cell death program | Cell Death and Differentiation | 2004 | 878 |
| 29 | Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics | Science | 2000 | 876 |
| 30 | An alternative, nonapoptotic form of programmed cell death | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 843 |
| 31 | Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 | Cell Death and Differentiation | 2015 | 811 |
| 32 | MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation | Nature Cell Biology | 2015 | 802 |
| 33 | A large-scale evaluation of computational protein function prediction | Nature Methods | 2013 | 789 |
| 34 | Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype | Cell Metabolism | 2016 | 776 |
| 35 | p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype | EMBO Journal | 2011 | 755 |
| 36 | Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling | Free Radical Biology and Medicine | 2016 | 753 |
| 37 | From discoveries in ageing research to therapeutics for healthy ageing | Nature | 2019 | 730 |
| 38 | Lamin B1 loss is a senescence-associated biomarker | Molecular Biology of the Cell | 2012 | 725 |
| 39 | Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population | Cell Metabolism | 2014 | 715 |
| 40 | The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 | Science | 2015 | 693 |
| 41 | Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B | Nature Medicine | 2012 | 682 |
| 42 | Characterization of the human heart mitochondrial proteome | Nature Biotechnology | 2003 | 665 |
| 43 | Senescence and apoptosis: dueling or complementary cell fates? | EMBO Reports | 2014 | 643 |
| 44 | Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma | Cancer Cell | 2017 | 642 |
| 45 | Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies | Molecular Cancer | 2006 | 635 |
| 46 | A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan | Cell Metabolism | 2015 | 635 |
| 47 | A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis | Nature | 2006 | 601 |
| 48 | Mitochondrial proton and electron leaks | Essays in Biochemistry | 2010 | 601 |
| 49 | Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes | Cell Death and Differentiation | 2009 | 599 |
| 50 | Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo | Neuron | 2003 | 594 |
