| # | Title | Journal | Year | Citations |
|---|
| 1 | Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence | Cell | 2003 | 1,991 |
| 2 | Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development | Science | 2004 | 736 |
| 3 | Predictive value of grade for metastasis development in the main histologic types of adult soft tissue sarcomas | Cancer | 2001 | 638 |
| 4 | Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): a single-group phase 2 study | Lancet Oncology, The | 2013 | 622 |
| 5 | Risk stratification of childhood medulloblastoma in the molecular era: the current consensus | Acta Neuropathologica | 2016 | 478 |
| 6 | Mechanical Induction of Twist in the Drosophila Foregut/Stomodeal Primordium | Current Biology | 2003 | 474 |
| 7 | Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin | Molecular and Cellular Biology | 2006 | 462 |
| 8 | A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced | Genes and Development | 2006 | 442 |
| 9 | Dosage compensation in mammals: fine-tuning the expression of the X chromosome | Genes and Development | 2006 | 439 |
| 10 | Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma | Journal of Clinical Oncology | 2010 | 426 |
| 11 | Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations? | Acta Neurologica Scandinavica | 1988 | 414 |
| 12 | Distinct Protein Sorting and Localization to Premelanosomes, Melanosomes, and Lysosomes in Pigmented Melanocytic Cells✪ | Journal of Cell Biology | 2001 | 393 |
| 13 | Prevalence of Renal Insufficiency in cancer patients and implications for anticancer drug management | Cancer | 2007 | 382 |
| 14 | Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts | Development (Cambridge) | 2005 | 352 |
| 15 | Structural and Functional Insights into the Myosin Motor Mechanism | Annual Review of Biophysics | 2010 | 352 |
| 16 | The Structure of a Human Type III Fcγ Receptor in Complex with Fc | Journal of Biological Chemistry | 2001 | 325 |
| 17 | Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation | Nature Cell Biology | 2006 | 304 |
| 18 | MDM4 is a key therapeutic target in cutaneous melanoma | Nature Medicine | 2012 | 266 |
| 19 | MULTIPLE GENETIC ALTERATIONS IN DISTAL AND PROXIMAL COLORECTAL CANCER | Lancet, The | 1989 | 257 |
| 20 | Recent advances in X-chromosome inactivation | Current Opinion in Cell Biology | 2004 | 253 |
| 21 | Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane | Nature Communications | 2017 | 252 |
| 22 | Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children | Lancet Oncology, The | 2005 | 250 |
| 23 | Metastatic osteosarcoma at diagnosis | Cancer | 2005 | 245 |
| 24 | In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 243 |
| 25 | SWI/SNF Chromatin Remodeling and Human Malignancies | Annual Review of Pathology: Mechanisms of Disease | 2015 | 242 |
| 26 | Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome | Molecular Cell | 2014 | 221 |
| 27 | The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak | EMBO Molecular Medicine | 2012 | 215 |
| 28 | Is obesity an independent prognosis factor in woman breast cancer? | Breast Cancer Research and Treatment | 2008 | 206 |
| 29 | Prevalence, intensity, and predictors of the supportive care needs of women diagnosed with breast cancer: a systematic review | Psycho-Oncology | 2014 | 199 |
| 30 | MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone | Modern Pathology | 2011 | 198 |
| 31 | Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression | Cell Death and Differentiation | 2014 | 195 |
| 32 | Differential Histone H3 Lys-9 and Lys-27 Methylation Profiles on the X Chromosome | Molecular and Cellular Biology | 2004 | 194 |
| 33 | Identification of a tight junction–associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability | Journal of Cell Biology | 2003 | 191 |
| 34 | Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies | Neuro-Oncology | 2016 | 185 |
| 35 | Lowe Syndrome Protein OCRL1 Interacts with Clathrin and Regulates Protein Trafficking between Endosomes and the Trans-Golgi Network | Molecular Biology of the Cell | 2005 | 184 |
| 36 | Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges | Proceedings of the National Academy of Sciences of the United States of America | 2018 | 181 |
| 37 | Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice | Nature | 2005 | 177 |
| 38 | Deconvolution Microscopy | Advances in Biochemical Engineering/Biotechnology | 2005 | 176 |
| 39 | Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia | Science | 2013 | 176 |
| 40 | Delving into the diversity of facultative heterochromatin: the epigenetics of the inactive X chromosome | Current Opinion in Genetics and Development | 2005 | 175 |
| 41 | Sensing X Chromosome Pairs Before X Inactivation via a Novel X-Pairing Region of the Xic | Science | 2007 | 171 |
| 42 | Mechanisms of Therapy Resistance in Patient-Derived Xenograft Models of BRCA1-Deficient Breast Cancer | Journal of the National Cancer Institute | 2016 | 157 |
| 43 | Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood | International Journal of Cancer | 1998 | 156 |
| 44 | Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions | Blood | 2011 | 156 |
| 45 | Role of Histone Methyltransferase G9a in CpG Methylation of the Prader-Willi Syndrome Imprinting Center | Journal of Biological Chemistry | 2003 | 149 |
| 46 | GLI2-Mediated Melanoma Invasion and Metastasis | Journal of the National Cancer Institute | 2010 | 149 |
| 47 | Safety and Efficacy of the Specific Endothelin-A Receptor Antagonist ZD4054 in Patients with Hormone-Resistant Prostate Cancer and Bone Metastases Who Were Pain Free or Mildly Symptomatic: A Double-Blind, Placebo-Controlled, Randomised, Phase 2 Trial | European Urology | 2009 | 141 |
| 48 | Analysis of Liver Cancer Cell Lines Identifies Agents With Likely Efficacy Against Hepatocellular Carcinoma and Markers of Response | Gastroenterology | 2019 | 141 |
| 49 | Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group | European Journal of Cancer | 2017 | 134 |
| 50 | Molecular subgrouping of atypical teratoid/rhabdoid tumors—a reinvestigation and current consensus | Neuro-Oncology | 2020 | 133 |
