| # | Title | Journal | Year | Citations |
|---|
| 1 | Image Quality Assessment: From Error Visibility to Structural Similarity | IEEE Transactions on Image Processing | 2004 | 34,925 |
| 2 | MicroRNAs: Target Recognition and Regulatory Functions | Cell | 2009 | 17,802 |
| 3 | Cluster analysis and display of genome-wide expression patterns | Proceedings of the National Academy of Sciences of the United States of America | 1998 | 14,487 |
| 4 | U1 snRNP regulates cancer cell migration and invasion in vitro | Nature Communications | 2020 | 12,921 |
| 5 | A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity | Science | 2012 | 12,811 |
| 6 | Positional cloning of the mouse obese gene and its human homologue | Nature | 1994 | 12,218 |
| 7 | Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 | Nature Biotechnology | 2019 | 11,167 |
| 8 | Integrins: Versatility, modulation, and signaling in cell adhesion | Cell | 1992 | 9,858 |
| 9 | Prospective identification of tumorigenic breast cancer cells | Proceedings of the National Academy of Sciences of the United States of America | 2003 | 9,314 |
| 10 | MicroRNA expression profiles classify human cancers | Nature | 2005 | 8,931 |
| 11 | Stem cells, cancer, and cancer stem cells | Nature | 2001 | 8,665 |
| 12 | An Information-Maximization Approach to Blind Separation and Blind Deconvolution | Neural Computation | 1995 | 7,791 |
| 13 | Integrins | Cell | 2002 | 7,714 |
| 14 | Imaging Intracellular Fluorescent Proteins at Nanometer Resolution | Science | 2006 | 7,580 |
| 15 | Finding the missing heritability of complex diseases | Nature | 2009 | 7,490 |
| 16 | Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 7,425 |
| 17 | The steroid and thyroid hormone receptor superfamily | Science | 1988 | 7,368 |
| 18 | Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA | Science | 1989 | 7,062 |
| 19 | INNATEIMMUNERECOGNITION | Annual Review of Immunology | 2002 | 6,871 |
| 20 | Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene | Annual Review of Immunology | 1998 | 6,776 |
| 21 | Foxp3 programs the development and function of CD4+CD25+ regulatory T cells | Nature Immunology | 2003 | 6,653 |
| 22 | Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade | Cell | 1997 | 6,625 |
| 23 | The nuclear receptor superfamily: The second decade | Cell | 1995 | 6,478 |
| 24 | The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity | Science | 1998 | 6,408 |
| 25 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 6,331 |
| 26 | Apoptosis in the pathogenesis and treatment of disease | Science | 1995 | 6,299 |
| 27 | Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm | Nature Protocols | 2009 | 6,149 |
| 28 | Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death | Cell | 1993 | 5,865 |
| 29 | Predicting effective microRNA target sites in mammalian mRNAs | ELife | 2015 | 5,779 |
| 30 | Integrative analysis of 111 reference human epigenomes | Nature | 2015 | 5,653 |
| 31 | A robust and high-throughput Cre reporting and characterization system for the whole mouse brain | Nature Neuroscience | 2010 | 5,650 |
| 32 | THE GREEN FLUORESCENT PROTEIN | Annual Review of Biochemistry | 1998 | 5,637 |
| 33 | The Genome Sequence of Drosophila melanogaster | Science | 2000 | 5,566 |
| 34 | Signal integration in the endoplasmic reticulum unfolded protein response | Nature Reviews Molecular Cell Biology | 2007 | 5,491 |
| 35 | Ultrasensitive fluorescent proteins for imaging neuronal activity | Nature | 2013 | 5,490 |
| 36 | Pfam: the protein families database | Nucleic Acids Research | 2014 | 5,425 |
| 37 | The Pfam protein families database: towards a more sustainable future | Nucleic Acids Research | 2016 | 5,391 |
| 38 | Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus | Cell | 2003 | 5,290 |
| 39 | Amino acid substitution matrices from protein blocks. | Proceedings of the National Academy of Sciences of the United States of America | 1992 | 5,230 |
| 40 | CDK inhibitors: positive and negative regulators of G1-phase progression | Genes and Development | 1999 | 5,227 |
| 41 | Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position | Nature Methods | 2013 | 5,209 |
| 42 | Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior | Cell | 1998 | 4,993 |
| 43 | Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1 | Science | 2009 | 4,989 |
| 44 | Cancer Cell Cycles | Science | 1996 | 4,932 |
| 45 | NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses | Annual Review of Immunology | 1998 | 4,878 |
| 46 | A human homologue of the Drosophila Toll protein signals activation of adaptive immunity | Nature | 1997 | 4,807 |
| 47 | The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation | Science | 2011 | 4,768 |
| 48 | Origin and physiological roles of inflammation | Nature | 2008 | 4,758 |
| 49 | Leptin and the regulation of body weight in mammals | Nature | 1998 | 4,702 |
| 50 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
