| # | Title | Journal | Year | Citations |
|---|
| 1 | Fast, scalable generation of high‐quality protein multiple sequence alignments using Clustal Omega | Molecular Systems Biology | 2011 | 12,778 |
| 2 | RoB 2: a revised tool for assessing risk of bias in randomised trials | BMJ: British Medical Journal | 2019 | 10,984 |
| 3 | ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | BMJ, The | 2016 | 8,654 |
| 4 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,060 |
| 5 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 6 | ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks | Bioinformatics | 2009 | 5,348 |
| 7 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 8 | Current Concepts in Mild Cognitive Impairment | Archives of Neurology | 2001 | 4,117 |
| 9 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
| 10 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 11 | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Nature Genetics | 2013 | 3,741 |
| 12 | Host-Gut Microbiota Metabolic Interactions | Science | 2012 | 3,693 |
| 13 | Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science | 2018 | 3,689 |
| 14 | Richness of human gut microbiome correlates with metabolic markers | Nature | 2013 | 3,641 |
| 15 | Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis | Journal of Innate Immunity | 2016 | 3,509 |
| 16 | Identification and characterization of a spinal muscular atrophy-determining gene | Cell | 1995 | 3,424 |
| 17 | Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies | Epilepsia | 2010 | 3,400 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 19 | Self-eating and self-killing: crosstalk between autophagy and apoptosis | Nature Reviews Molecular Cell Biology | 2007 | 3,105 |
| 20 | Autophagy and the Integrated Stress Response | Molecular Cell | 2010 | 2,982 |
| 21 | Second consensus statement on the diagnosis of multiple system atrophy | Neurology | 2008 | 2,720 |
| 22 | Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy | Nature Medicine | 2007 | 2,657 |
| 23 | A genome-wide association study identifies novel risk loci for type 2 diabetes | Nature | 2007 | 2,651 |
| 24 | Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 | Cell Death and Differentiation | 2009 | 2,572 |
| 25 | A new variant of Creutzfeldt-Jakob disease in the UK | Lancet, The | 1996 | 2,554 |
| 26 | Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota | Science | 2015 | 2,539 |
| 27 | Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms | New England Journal of Medicine | 2011 | 2,491 |
| 28 | Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease | Nature Genetics | 2008 | 2,422 |
| 29 | Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients | Science | 2020 | 2,374 |
| 30 | Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel | European Heart Journal | 2017 | 2,292 |
| 31 | Human Splicing Finder: an online bioinformatics tool to predict splicing signals | Nucleic Acids Research | 2009 | 2,206 |
| 32 | Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012 | Cell Death and Differentiation | 2012 | 2,144 |
| 33 | Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society | European Heart Journal | 2013 | 2,132 |
| 34 | KRAS Mutation Status Is Predictive of Response to Cetuximab Therapy in Colorectal Cancer | Cancer Research | 2006 | 2,116 |
| 35 | Molecular mechanisms of cisplatin resistance | Oncogene | 2012 | 2,058 |
| 36 | Innate lymphoid cells — a proposal for uniform nomenclature | Nature Reviews Immunology | 2013 | 2,054 |
| 37 | A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease | Nature Genetics | 2015 | 2,054 |
| 38 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies | Nature Reviews Drug Discovery | 2019 | 2,005 |
| 39 | Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer | JAMA - Journal of the American Medical Association | 2017 | 2,003 |
| 40 | Autoantibodies against type I IFNs in patients with life-threatening COVID-19 | Science | 2020 | 1,983 |
| 41 | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk | Nature Genetics | 2010 | 1,982 |
| 42 | Estimating the population abundance of tissue-infiltrating immune and stromal cell populations using gene expression | Genome Biology | 2016 | 1,980 |
| 43 | SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues | Cell | 2020 | 1,956 |
| 44 | Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression | Nature Genetics | 2001 | 1,954 |
| 45 | Molecular mechanisms of necroptosis: an ordered cellular explosion | Nature Reviews Molecular Cell Biology | 2010 | 1,941 |
| 46 | Tumor Cell Metabolism: Cancer's Achilles' Heel | Cancer Cell | 2008 | 1,926 |
| 47 | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis | Lancet Oncology, The | 2010 | 1,915 |
| 48 | A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease | Alzheimer's and Dementia | 2014 | 1,863 |
| 49 | Hepatocellular carcinoma | Nature Reviews Disease Primers | 2016 | 1,863 |
| 50 | Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization | Nature | 2021 | 1,803 |
