| # | Title | Journal | Year | Citations |
|---|
| 1 | QIIME allows analysis of high-throughput community sequencing data | Nature Methods | 2010 | 31,818 |
| 2 | Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase | Science | 1990 | 9,174 |
| 3 | Astropy: A community Python package for astronomy | Astronomy and Astrophysics | 2013 | 8,416 |
| 4 | Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences | Nature Biotechnology | 2013 | 8,049 |
| 5 | Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms | ISME Journal | 2012 | 7,430 |
| 6 | Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample | Proceedings of the National Academy of Sciences of the United States of America | 2011 | 7,425 |
| 7 | UniFrac: a New Phylogenetic Method for Comparing Microbial Communities | Applied and Environmental Microbiology | 2005 | 7,007 |
| 8 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 9 | A core gut microbiome in obese and lean twins | Nature | 2009 | 6,819 |
| 10 | Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma | New England Journal of Medicine | 2015 | 6,773 |
| 11 | Human gut microbiome viewed across age and geography | Nature | 2012 | 6,247 |
| 12 | Observation of Bose-Einstein Condensation in a Dilute Atomic Vapor | Science | 1995 | 5,988 |
| 13 | Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II) | Journal of Vascular Surgery | 2007 | 5,618 |
| 14 | Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes | Science | 2011 | 5,253 |
| 15 | Transformation of the Nitrogen Cycle: Recent Trends, Questions, and Potential Solutions | Science | 2008 | 5,246 |
| 16 | Computer Visualization of Three-Dimensional Image Data Using IMOD | Journal of Structural Biology | 1996 | 4,964 |
| 17 | Tabu Search—Part I | ORSA Journal on Computing | 1989 | 4,815 |
| 18 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 19 | Atomic Layer Deposition: An Overview | Chemical Reviews | 2010 | 4,663 |
| 20 | Automated electron microscope tomography using robust prediction of specimen movements | Journal of Structural Biology | 2005 | 4,320 |
| 21 | Bounding the role of black carbon in the climate system: A scientific assessment | Journal of Geophysical Research D: Atmospheres | 2013 | 4,319 |
| 22 | Nitrogen Cycles: Past, Present, and Future | Biogeochemistry | 2004 | 4,203 |
| 23 | Diversity, stability and resilience of the human gut microbiota | Nature | 2012 | 4,114 |
| 24 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 25 | Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 3,871 |
| 26 | Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns | Proceedings of the National Academy of Sciences of the United States of America | 2010 | 3,738 |
| 27 | TOWARD AN ECOLOGICAL CLASSIFICATION OF SOIL BACTERIA | Ecology | 2007 | 3,728 |
| 28 | Ferroelectric Memories | Science | 1989 | 3,585 |
| 29 | Detection of the Baryon Acoustic Peak in the Large‐Scale Correlation Function of SDSS Luminous Red Galaxies | Astrophysical Journal | 2005 | 3,564 |
| 30 | Tabu Search—Part II | ORSA Journal on Computing | 1990 | 3,561 |
| 31 | Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin | Nature | 2000 | 3,524 |
| 32 | Primary, Secondary, and Meta-Analysis of Research | Educational Researcher | 1976 | 3,482 |
| 33 | An introduction to latent semantic analysis | Discourse Processes | 1998 | 3,430 |
| 34 | Quality-filtering vastly improves diversity estimates from Illumina amplicon sequencing | Nature Methods | 2013 | 3,402 |
| 35 | Evolution of Organic Aerosols in the Atmosphere | Science | 2009 | 3,374 |
| 36 | Thiol–Ene Click Chemistry | Angewandte Chemie - International Edition | 2010 | 3,333 |
| 37 | Colorectal cancer statistics, 2017 | Ca-A Cancer Journal for Clinicians | 2017 | 3,300 |
| 38 | Pyrosequencing-Based Assessment of Soil pH as a Predictor of Soil Bacterial Community Structure at the Continental Scale | Applied and Environmental Microbiology | 2009 | 3,268 |
| 39 | Evolution of Mammals and Their Gut Microbes | Science | 2008 | 3,171 |
| 40 | Soil bacterial and fungal communities across a pH gradient in an arable soil | ISME Journal | 2010 | 3,154 |
| 41 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 42 | Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice | Science | 2013 | 3,006 |
| 43 | Towards a unified paradigm for sequence‐based identification of fungi | Molecular Ecology | 2013 | 2,997 |
| 44 | Future paths for integer programming and links to artificial intelligence | Computers and Operations Research | 1986 | 2,995 |
| 45 | IPython: A System for Interactive Scientific Computing | Computing in Science and Engineering | 2007 | 2,952 |
| 46 | Next-generation genotype imputation service and methods | Nature Genetics | 2016 | 2,828 |
| 47 | Validity of the Executive Function Theory of Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review | Biological Psychiatry | 2005 | 2,761 |
| 48 | Statistical difficulties of detecting interactions and moderator effects. | Psychological Bulletin | 1993 | 2,718 |
| 49 | Bacterial Community Variation in Human Body Habitats Across Space and Time | Science | 2009 | 2,713 |
| 50 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease | Cell Host and Microbe | 2014 | 2,582 |
