| # | Title | Journal | Year | Citations |
|---|
| 1 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 2 | AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 | Nature Cell Biology | 2011 | 5,447 |
| 3 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 4 | Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? | Nature Reviews Drug Discovery | 2009 | 4,327 |
| 5 | Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors | Science | 2018 | 3,689 |
| 6 | The consensus molecular subtypes of colorectal cancer | Nature Medicine | 2015 | 3,596 |
| 7 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 8 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 9 | Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension | Lancet, The | 1997 | 2,841 |
| 10 | Hepatocellular carcinoma | Nature Reviews Disease Primers | 2021 | 2,757 |
| 11 | Treatment of Hypertension in Patients 80 Years of Age or Older | New England Journal of Medicine | 2008 | 2,714 |
| 12 | When moderation is mediated and mediation is moderated. | Journal of Personality and Social Psychology | 2005 | 2,647 |
| 13 | Calreticulin exposure dictates the immunogenicity of cancer cell death | Nature Medicine | 2007 | 2,580 |
| 14 | Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics | Nature | 1990 | 2,565 |
| 15 | Mutations in PCSK9 cause autosomal dominant hypercholesterolemia | Nature Genetics | 2003 | 2,532 |
| 16 | OARSI guidelines for the non-surgical management of knee osteoarthritis | Osteoarthritis and Cartilage | 2014 | 2,298 |
| 17 | A sensorimotor account of vision and visual consciousness | Behavioral and Brain Sciences | 2001 | 2,295 |
| 18 | PI-RADS Prostate Imaging – Reporting and Data System: 2015, Version 2 | European Urology | 2016 | 2,290 |
| 19 | Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease | Nature Genetics | 2009 | 2,155 |
| 20 | The European Spondylarthropathy Study Group Preliminary Criteria for the Classification of Spondylarthropathy | Arthritis and Rheumatism | 1991 | 2,120 |
| 21 | Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy | Science | 2011 | 2,107 |
| 22 | A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells | Science | 2012 | 2,084 |
| 23 | Approaches to treat immune hot, altered and cold tumours with combination immunotherapies | Nature Reviews Drug Discovery | 2019 | 2,005 |
| 24 | Glial and neuronal control of brain blood flow | Nature | 2010 | 2,003 |
| 25 | Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing | Nature Genetics | 2019 | 1,962 |
| 26 | Moving beyond Kučera and Francis: A critical evaluation of current word frequency norms and the introduction of a new and improved word frequency measure for American English | Behavior Research Methods | 2009 | 1,932 |
| 27 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial | Lancet Oncology, The | 2014 | 1,932 |
| 28 | Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis | Lancet Oncology, The | 2010 | 1,915 |
| 29 | A Phase 3 Trial of Bevacizumab in Ovarian Cancer | New England Journal of Medicine | 2011 | 1,843 |
| 30 | Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies | JAMA - Journal of the American Medical Association | 2018 | 1,783 |
| 31 | Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease | Nature Genetics | 2011 | 1,708 |
| 32 | A classification of chronic pain for ICD-11 | Pain | 2015 | 1,701 |
| 33 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update | Annals of the Rheumatic Diseases | 2014 | 1,688 |
| 34 | Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene | Nature | 1996 | 1,652 |
| 35 | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors | Nature Medicine | 2009 | 1,614 |
| 36 | Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO) | Kidney International | 2006 | 1,586 |
| 37 | Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11) | Pain | 2019 | 1,547 |
| 38 | Boceprevir for Previously Treated Chronic HCV Genotype 1 Infection | New England Journal of Medicine | 2011 | 1,538 |
| 39 | Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1 | Journal of Clinical Investigation | 2008 | 1,531 |
| 40 | Endarterectomy versus Stenting in Patients with Symptomatic Severe Carotid Stenosis | New England Journal of Medicine | 2006 | 1,467 |
| 41 | Telaprevir for Retreatment of HCV Infection | New England Journal of Medicine | 2011 | 1,466 |
| 42 | Rituximab for rheumatoid arthritis refractory to anti–tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks | Arthritis and Rheumatism | 2006 | 1,462 |
| 43 | Immediate Coronary Angiography in Survivors of Out-of-Hospital Cardiac Arrest | New England Journal of Medicine | 1997 | 1,437 |
| 44 | Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 | Autophagy | 2021 | 1,430 |
| 45 | A candidate gene for familial Mediterranean fever | Nature Genetics | 1997 | 1,402 |
| 46 | Variation in FTO contributes to childhood obesity and severe adult obesity | Nature Genetics | 2007 | 1,390 |
| 47 | Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial | Lancet Oncology, The | 2017 | 1,376 |
| 48 | The molecular machinery of regulated cell death | Cell Research | 2019 | 1,373 |
| 49 | Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial | Lancet, The | 1998 | 1,336 |
| 50 | SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx | Nature | 2011 | 1,330 |
