| # | Title | Journal | Year | Citations |
|---|
| 1 | Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling | Nature | 2000 | 8,977 |
| 2 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 3 | Targeting HIF-1 for cancer therapy | Nature Reviews Cancer | 2003 | 6,111 |
| 4 | Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2009 | 6,039 |
| 5 | Why Don't Physicians Follow Clinical Practice Guidelines? | JAMA - Journal of the American Medical Association | 1999 | 5,548 |
| 6 | THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES | Journal of Histochemistry and Cytochemistry | 1970 | 5,230 |
| 7 | Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade | Science | 2017 | 4,945 |
| 8 | Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown | Nature Protocols | 2016 | 4,743 |
| 9 | A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease | Nature | 2001 | 4,589 |
| 10 | Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040 | Ophthalmology | 2014 | 4,514 |
| 11 | Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment | Journal of Internal Medicine | 2004 | 4,039 |
| 12 | Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment | Developmental Cell | 2004 | 3,799 |
| 13 | Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 | Cell | 2004 | 3,626 |
| 14 | Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α | Cell | 2006 | 3,603 |
| 15 | Functional architecture of basal ganglia circuits: neural substrates of parallel processing | Trends in Neurosciences | 1990 | 3,595 |
| 16 | Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1 | Molecular and Cellular Biology | 1996 | 3,560 |
| 17 | STATs in cancer inflammation and immunity: a leading role for STAT3 | Nature Reviews Cancer | 2009 | 3,503 |
| 18 | Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging | Annals of Neurology | 1999 | 3,317 |
| 19 | Alzheimer's disease: a disorder of cortical cholinergic innervation | Science | 1983 | 3,043 |
| 20 | Localization of nitric oxide synthase indicating a neural role for nitric oxide | Nature | 1990 | 2,959 |
| 21 | Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis | Lancet Neurology, The | 2015 | 2,776 |
| 22 | Hearing Loss and Cognitive Decline in Older Adults | JAMA Internal Medicine | 2013 | 2,721 |
| 23 | Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology | Canadian Journal of Gastroenterology & Hepatology | 2005 | 2,711 |
| 24 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,700 |
| 25 | Integrative Clinical Genomics of Advanced Prostate Cancer | Cell | 2015 | 2,660 |
| 26 | The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After | Surgery | 2017 | 2,655 |
| 27 | Diagnosis, management, and treatment of hepatitis C: An update | Hepatology | 2009 | 2,610 |
| 28 | Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers | Journal of the National Cancer Institute | 2000 | 2,586 |
| 29 | Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell | Cell | 2001 | 2,571 |
| 30 | Cellular uptake of the tat protein from human immunodeficiency virus | Cell | 1988 | 2,563 |
| 31 | A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants | Science | 2007 | 2,534 |
| 32 | Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE | Nature | 1994 | 2,471 |
| 33 | The chemical diversity and distribution of glucosinolates and isothiocyanates among plants | Phytochemistry | 2001 | 2,435 |
| 34 | Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas | Gastroenterology | 1994 | 2,329 |
| 35 | Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men | Journal of Clinical Endocrinology and Metabolism | 2001 | 2,275 |
| 36 | MDAnalysis: A toolkit for the analysis of molecular dynamics simulations | Journal of Computational Chemistry | 2011 | 2,201 |
| 37 | Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality | Annals of Internal Medicine | 2005 | 2,182 |
| 38 | The prevalence of psychological distress by cancer site | Psycho-Oncology | 2001 | 2,164 |
| 39 | Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles | Journal of Extracellular Vesicles | 2014 | 2,110 |
| 40 | Human Mesenchymal Stem Cells Differentiate to a Cardiomyocyte Phenotype in the Adult Murine Heart | Circulation | 2002 | 2,078 |
| 41 | Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008 | Intensive Care Medicine | 2008 | 2,078 |
| 42 | Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma | Cancer Cell | 2010 | 2,078 |
| 43 | A simplified method for cyanogen bromide activation of agarose for affinity chromatography | Analytical Biochemistry | 1974 | 2,050 |
| 44 | The development and initial validation of the systemic lupus international collaborating clinics/American college of rheumatology damage index for systemic lupus erythematosus | Arthritis and Rheumatism | 1996 | 2,042 |
| 45 | A framework for advancing our understanding of cancer-associated fibroblasts | Nature Reviews Cancer | 2020 | 2,012 |
| 46 | Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas | Science | 1989 | 1,945 |
| 47 | Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene | Nature | 1991 | 1,901 |
| 48 | Function and Regulation of CREB Family Transcription Factors in the Nervous System | Neuron | 2002 | 1,865 |
| 49 | HIF-1: mediator of physiological and pathophysiological responses to hypoxia | Journal of Applied Physiology | 2000 | 1,855 |
| 50 | Mutation of a mutL homolog in hereditary colon cancer | Science | 1994 | 1,821 |
