| # | Title | Journal | Year | Citations |
|---|
| 1 | The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 12,681 |
| 2 | A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 | Science | 1994 | 5,747 |
| 3 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 4 | Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial | Lancet, The | 2005 | 3,840 |
| 5 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 6 | How to improve R&D productivity: the pharmaceutical industry's grand challenge | Nature Reviews Drug Discovery | 2010 | 2,750 |
| 7 | The World Health Organization adult ADHD self-report scale (ASRS): a short screening scale for use in the general population | Psychological Medicine | 2005 | 2,316 |
| 8 | A systematic review of the associations between dose regimens and medication compliance | Clinical Therapeutics | 2001 | 2,040 |
| 9 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial | Lancet Oncology, The | 2014 | 1,932 |
| 10 | Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects | Annals of Neurology | 2009 | 1,803 |
| 11 | Circulating Ghrelin Levels Are Decreased in Human Obesity | Diabetes | 2001 | 1,786 |
| 12 | Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial | Lancet, The | 2019 | 1,625 |
| 13 | The role of neuropeptide Y in the antiobesity action of the obese gene product | Nature | 1995 | 1,491 |
| 14 | The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis | Neuron | 2003 | 1,465 |
| 15 | Key green chemistry research areas—a perspective from pharmaceutical manufacturers | Green Chemistry | 2007 | 1,371 |
| 16 | Detailed analysis of grid-based molecular docking: A case study of CDOCKER?A CHARMm-based MD docking algorithm | Journal of Computational Chemistry | 2003 | 1,299 |
| 17 | The IKK NF-κB system: a treasure trove for drug development | Nature Reviews Drug Discovery | 2004 | 1,263 |
| 18 | Regulation of bone mass by Wnt signaling | Journal of Clinical Investigation | 2006 | 1,211 |
| 19 | Amorphous pharmaceutical solids: preparation, characterization and stabilization | Advanced Drug Delivery Reviews | 2001 | 1,183 |
| 20 | The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse | Osteoarthritis and Cartilage | 2010 | 1,151 |
| 21 | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer | Nature | 2007 | 1,117 |
| 22 | Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo | Neuron | 2005 | 1,060 |
| 23 | Biological, Physiological, Pathophysiological, and Pharmacological Aspects of Ghrelin | Endocrine Reviews | 2004 | 1,057 |
| 24 | Resistance to Antibiotics: Are We in the Post-Antibiotic Era? | Archives of Medical Research | 2005 | 1,048 |
| 25 | Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance | Cell Metabolism | 2007 | 1,048 |
| 26 | The Prevalence of Chronic Pain in United States Adults: Results of an Internet-Based Survey | Journal of Pain | 2010 | 1,038 |
| 27 | Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions? | Environmental Health Perspectives | 2012 | 1,033 |
| 28 | Pharmacological agents acting at subtypes of metabotropic glutamate receptors | Neuropharmacology | 1999 | 1,025 |
| 29 | Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial | Nature Medicine | 2007 | 1,003 |
| 30 | Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study | Lancet, The | 2008 | 960 |
| 31 | Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature | 2022 | 929 |
| 32 | Alzheimer's disease: strategies for disease modification | Nature Reviews Drug Discovery | 2010 | 928 |
| 33 | Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine | Neuropsychopharmacology | 1996 | 924 |
| 34 | Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance | Science Translational Medicine | 2011 | 924 |
| 35 | An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT | Journal of Immunological Methods | 1991 | 908 |
| 36 | Insulin-like growth factor II receptor as a multifunctional binding protein | Nature | 1987 | 878 |
| 37 | Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model | Nature Neuroscience | 2002 | 873 |
| 38 | Olanzapine versus haloperidol in the treatment of schizophrenia and schizoaffective and schizophreniform disorders: results of an international collaborative trial | American Journal of Psychiatry | 1997 | 862 |
| 39 | Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects | Nature Genetics | 2017 | 838 |
| 40 | The Human Hepatic Cytochromes P450 Involved in Drug Metabolism | Critical Reviews in Toxicology | 1992 | 825 |
| 41 | Noncalcemic Actions of Vitamin D Receptor Ligands | Endocrine Reviews | 2005 | 813 |
| 42 | Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19 | JAMA - Journal of the American Medical Association | 2021 | 803 |
| 43 | Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition | Nature Genetics | 1997 | 796 |
| 44 | Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors | Journal of Neurochemistry | 2002 | 794 |
| 45 | Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain | Journal of Neurochemistry | 2009 | 780 |
| 46 | Ramucirumab versus placebo in combination with second-line FOLFIRI in patients with metastatic colorectal carcinoma that progressed during or after first-line therapy with bevacizumab, oxaliplatin, and a fluoropyrimidine (RAISE): a randomised, double-blind, multicentre, phase 3 study | Lancet Oncology, The | 2015 | 753 |
| 47 | Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin | Nature Medicine | 2011 | 751 |
| 48 | Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control | Molecular and Cellular Biology | 1998 | 737 |
| 49 | Ghrelin octanoylation mediated by an orphan lipid transferase | Proceedings of the National Academy of Sciences of the United States of America | 2008 | 735 |
| 50 | Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials | Lancet, The | 2015 | 719 |
