| Quantitative evidence for global amphibian population declines | Nature | 2000 | 923 |
| Endocrine and paracrine regulation of birth at term and preterm | Endocrine Reviews | 2000 | 651 |
| Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus | Nature Medicine | 2000 | 639 |
| On the Assessment of Situational Intrinsic and Extrinsic Motivation: The Situational Motivation Scale (SIMS) | Motivation and Emotion | 2000 | 598 |
| Plasmon-polariton waves guided by thin lossy metal films of finite width: Bound modes of symmetric structures | Physical Review B | 2000 | 567 |
| Does the inclusion of grey literature influence estimates of intervention effectiveness reported in meta-analyses? | Lancet, The | 2000 | 539 |
| Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo | Journal of Immunology | 2000 | 512 |
| Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes | American Journal of Physiology - Cell Physiology | 2000 | 440 |
| What contributions do languages other than English make on the results of meta-analyses? | Journal of Clinical Epidemiology | 2000 | 377 |
| Factors predicting response to treatment in rheumatoid arthritis: the importance of disease duration | Arthritis and Rheumatism | 2000 | 360 |
| Irritable bowel syndrome in general practice: prevalence, characteristics, and referral | Gut | 2000 | 339 |
| Why Are You Learning a Second Language? Motivational Orientations and Self-Determination Theory | Language Learning | 2000 | 338 |
| An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures | Phytomedicine | 2000 | 289 |
| A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain | Journal of Neuroscience | 2000 | 275 |
| Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer | Thrombosis and Haemostasis | 2000 | 266 |
| Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter | Journal of Neuroscience | 2000 | 254 |
| Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells | Cancer Research | 2000 | 244 |
| Immunogold evidence that neuronal gap junctions in adult rat brain and spinal cord contain connexin-36 but not connexin-32 or connexin-43 | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 238 |
| Experimental observation of plasmon polariton waves supported by a thin metal film of finite width | Optics Letters | 2000 | 236 |
| Cognitive–behavioral treatment of insomnia secondary to chronic pain. | Journal of Consulting and Clinical Psychology | 2000 | 234 |
| Cyclin-dependent kinases as a therapeutic target for stroke | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 233 |
| Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death | Oncogene | 2000 | 225 |
| Predictions of binary sorption isotherms for the sorption of heavy metals by pine bark using single isotherm data | Chemosphere | 2000 | 213 |
| A role for platelets and endothelial selectins in tumor necrosis factor-alpha-induced leukocyte recruitment in the brain microvasculature | Circulation Research | 2000 | 212 |
| Insulin sensitivity and its measurement: structural commonalities among the methods | Journal of Clinical Endocrinology and Metabolism | 2000 | 208 |
