| # | Title | Journal | Year | Citations |
|---|
| 1 | RNA interference | Nature | 2002 | 3,760 |
| 2 | Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAi | Science | 2001 | 1,361 |
| 3 | A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons | Science | 2007 | 1,094 |
| 4 | Unlocking the potential of the human genome with RNA interference | Nature | 2004 | 1,013 |
| 5 | Tackling antibiotic resistance | Nature Reviews Microbiology | 2011 | 919 |
| 6 | Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary | Cell | 2009 | 774 |
| 7 | Small RNAs as Guardians of the Genome | Cell | 2009 | 763 |
| 8 | Characterization of Dicer-deficient murine embryonic stem cells | Proceedings of the National Academy of Sciences of the United States of America | 2005 | 742 |
| 9 | Cortical rewiring and information storage | Nature | 2004 | 675 |
| 10 | Genome-wide in situ exon capture for selective resequencing | Nature Genetics | 2007 | 635 |
| 11 | Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis | Science | 2008 | 609 |
| 12 | Analysis of the C. elegans Argonaute Family Reveals that Distinct Argonautes Act Sequentially during RNAi | Cell | 2006 | 576 |
| 13 | A genome triplication associated with early diversification of the core eudicots | Genome Biology | 2012 | 389 |
| 14 | Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization | Genes and Development | 2007 | 360 |
| 15 | The CRISPR System: Small RNA-Guided Defense in Bacteria and Archaea | Molecular Cell | 2010 | 331 |
| 16 | Long non-coding RNAs: definitions, functions, challenges and recommendations | Nature Reviews Molecular Cell Biology | 2023 | 313 |
| 17 | Corticostriatal neurons in auditory cortex drive decisions during auditory discrimination | Nature | 2013 | 300 |
| 18 | Structural Basis for the EBA-175 Erythrocyte Invasion Pathway of the Malaria Parasite Plasmodium falciparum | Cell | 2005 | 289 |
| 19 | Improving the efficiency of RNA interference in mammals | Nature Reviews Genetics | 2004 | 276 |
| 20 | Directional DNA Methylation Changes and Complex Intermediate States Accompany Lineage Specificity in the Adult Hematopoietic Compartment | Molecular Cell | 2011 | 261 |
| 21 | Computational prediction of eukaryotic protein-coding genes | Nature Reviews Genetics | 2002 | 244 |
| 22 | Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors | Cancer Cell | 2003 | 238 |
| 23 | XXXIII.The theory of electrolytic polarization | The London, Edinburgh and Dublin Philosophical Magazine and Journal of Science | 1932 | 221 |
| 24 | Inducible, reversible, and stable RNA interference in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 214 |
| 25 | Genome-Wide Methylation Analysis and Epigenetic Unmasking Identify Tumor Suppressor Genes in Hepatocellular Carcinoma | Gastroenterology | 2013 | 204 |
| 26 | Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer | Proceedings of the National Academy of Sciences of the United States of America | 2007 | 203 |
| 27 | Rap2-JNK Removes Synaptic AMPA Receptors during Depotentiation | Neuron | 2005 | 181 |
| 28 | RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells | Proceedings of the National Academy of Sciences of the United States of America | 2004 | 174 |
| 29 | Diverse Endonucleolytic Cleavage Sites in the Mammalian Transcriptome Depend upon MicroRNAs, Drosha, and Additional Nucleases | Molecular Cell | 2010 | 170 |
| 30 | Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication | Science | 2014 | 165 |
| 31 | Non-germline genetically engineered mouse models for translational cancer research | Nature Reviews Cancer | 2010 | 161 |
| 32 | High-Throughput Selection of Effective RNAi Probes for Gene Silencing | Genome Research | 2003 | 154 |
| 33 | Next-Generation Sequencing Technologies | Cold Spring Harbor Perspectives in Medicine | 2019 | 143 |
| 34 | The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR | Journal of Biological Chemistry | 1997 | 137 |
| 35 | Dephosphorylation of the C-terminal Tyrosyl Residue of the DNA Damage-related Histone H2A.X Is Mediated by the Protein Phosphatase Eyes Absent | Journal of Biological Chemistry | 2009 | 122 |
| 36 | RNA discrimination | Nature | 2012 | 104 |
| 37 | Identification of the Cell Cycle Regulator VCP (p97/CDC48) as a Substrate of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 | Journal of Biological Chemistry | 1999 | 91 |
| 38 | Gene Mutations and Genomic Rearrangements in the Mouse as a Result of Transposon Mobilization from Chromosomal Concatemers | PLoS Genetics | 2006 | 90 |
| 39 | A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models | Journal of Biological Chemistry | 2018 | 90 |
| 40 | Diagnosis, Prognosis, and Treatment of Alveolar Soft-Part Sarcoma | JAMA Oncology | 2019 | 89 |
| 41 | An Epigenetic Memory of Pregnancy in the Mouse Mammary Gland | Cell Reports | 2015 | 88 |
| 42 | Redefining Genomic Privacy: Trust and Empowerment | PLoS Biology | 2014 | 87 |
| 43 | Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury | Brain | 2019 | 83 |
| 44 | STUDIES ON THE PHYSIOLOGY OF REPRODUCTION IN BIRDS | American Journal of Physiology | 1926 | 80 |
| 45 | Sensitivity of Cancer Cells to Plk1 Inhibitor GSK461364A Is Associated with Loss of p53 Function and Chromosome Instability | Molecular Cancer Therapeutics | 2010 | 80 |
| 46 | From cancer genomes to oncogenic drivers, tumour dependencies and therapeutic targets | Nature Reviews Cancer | 2012 | 76 |
| 47 | Expressed sequence tag analysis in Cycas, the most primitive living seed plant | Genome Biology | 2003 | 74 |
| 48 | Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4 | Nature Communications | 2014 | 72 |
| 49 | Activation of multiple cancer pathways and tumor maintenance function of the 3q amplified oncogeneFNDC3B | Cell Cycle | 2012 | 70 |
| 50 | Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification | EMBO Journal | 2007 | 69 |
