| # | Title | Journal | Year | Citations |
|---|
| 1 | Intravitreal Aflibercept (VEGF Trap-Eye) in Wet Age-related Macular Degeneration | Ophthalmology | 2012 | 1,947 |
| 2 | Genetic Analysis of Human Norovirus Strains in Japan in 2016–2017 | Frontiers in Microbiology | 2018 | 1,397 |
| 3 | G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis | Genes and Development | 2002 | 1,084 |
| 4 | Mutations in the human Jagged1 gene are responsible for Alagille syndrome | Nature Genetics | 1997 | 1,072 |
| 5 | The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014) | Hypertension Research | 2014 | 962 |
| 6 | Antibody-Mediated Rejection Criteria - an Addition to the Banff ′97 Classification of Renal Allograft Rejection | American Journal of Transplantation | 2003 | 960 |
| 7 | Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011 | Modern Rheumatology | 2012 | 947 |
| 8 | TRB3, a novel ER stress-inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death | EMBO Journal | 2005 | 868 |
| 9 | Significance of serum hepatitis C virus RNA levels in chronic hepatitis C | Lancet, The | 1993 | 864 |
| 10 | Association between Body-Mass Index and Risk of Death in More Than 1 Million Asians | New England Journal of Medicine | 2011 | 730 |
| 11 | Mutational landscape and clonal architecture in grade II and III gliomas | Nature Genetics | 2015 | 729 |
| 12 | Intravitreal Aflibercept Injection for Neovascular Age-related Macular Degeneration | Ophthalmology | 2014 | 693 |
| 13 | DO NATURAL DISASTERS PROMOTE LONG-RUN GROWTH? | Economic Inquiry | 2002 | 674 |
| 14 | Standard steroid treatment for autoimmune pancreatitis | Gut | 2009 | 630 |
| 15 | Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth | Cancers | 2015 | 616 |
| 16 | Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study | Journal of Clinical Oncology | 2012 | 581 |
| 17 | The Surface of Lipid Droplets Is a Phospholipid Monolayer with a Unique Fatty Acid Composition | Journal of Biological Chemistry | 2002 | 576 |
| 18 | Economic development and the impacts of natural disasters | Economics Letters | 2007 | 552 |
| 19 | HJURP Is a Cell-Cycle-Dependent Maintenance and Deposition Factor of CENP-A at Centromeres | Cell | 2009 | 552 |
| 20 | Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption | Nature Genetics | 2001 | 539 |
| 21 | Stimulation of FcγRI on Primary Sensory Neurons Increases Insulin-Like Growth Factor-I Production, Thereby Reducing Reperfusion-Induced Renal Injury in Mice | Journal of Immunology | 2010 | 524 |
| 22 | Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss | Lancet, The | 2021 | 508 |
| 23 | Current states and future views in photodynamic therapy | Journal of Photochemistry and Photobiology C: Photochemistry Reviews | 2011 | 457 |
| 24 | Studies on antioxidants: Their carcinogenic and modifying effects on chemical carcinogenesis | Food and Chemical Toxicology | 1986 | 450 |
| 25 | TRPV2 Is a Component of Osmotically Sensitive Cation Channels in Murine Aortic Myocytes | Circulation Research | 2003 | 450 |
| 26 | Nicotianamine Chelates Both FeIII and FeII. Implications for Metal Transport in Plants1 | Plant Physiology | 1999 | 443 |
| 27 | Classification, nomenclature, and database development for hepatitis C virus (HCV) and related viruses: proposals for standardization | Archives of Virology | 1998 | 427 |
| 28 | Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice | Genes and Development | 2000 | 397 |
| 29 | Serum Lysophosphatidic Acid Is Produced through Diverse Phospholipase Pathways | Journal of Biological Chemistry | 2002 | 375 |
| 30 | DNA damage checkpoints in mammals | Mutagenesis | 2006 | 366 |
| 31 | Estrogenic Activities of 517 Chemicals by Yeast Two-Hybrid Assay. | Journal of Health Science | 2000 | 364 |
| 32 | EBV-associated T/NK–cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases | Blood | 2012 | 354 |
| 33 | MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL | Cancer Cell | 2005 | 349 |
| 34 | Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events | Neuron | 2011 | 345 |
| 35 | Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly | Hypertension | 2010 | 334 |
| 36 | Identification of Viruses in Patients With Postviral Olfactory Dysfunction | Laryngoscope | 2007 | 325 |
| 37 | Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction | British Journal of Cancer | 2014 | 318 |
| 38 | INTERSTELLAR EXTINCTION LAW TOWARD THE GALACTIC CENTER III:J,H,KSBANDS IN THE 2MASS AND THE MKO SYSTEMS, AND 3.6, 4.5, 5.8, 8.0 μm IN THESPITZER/IRAC SYSTEM | Astrophysical Journal | 2009 | 316 |
| 39 | Clinical diagnostic criteria of IgG4‐related sclerosing cholangitis 2012 | Journal of Hepato-Biliary-Pancreatic Sciences | 2012 | 309 |
| 40 | Eukaryotic DNA Polymerases: Proposal for a Revised Nomenclature | Journal of Biological Chemistry | 2001 | 307 |
| 41 | A novel phosphor for glareless white light-emitting diodes | Nature Communications | 2012 | 306 |
| 42 | Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication | Nature | 2013 | 305 |
| 43 | Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction | Neuroscience Research | 2006 | 300 |
| 44 | Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin | Biochemical Journal | 1986 | 296 |
| 45 | Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms | Cell | 2015 | 296 |
| 46 | Glycosylphosphatidylinositol (GPI)-Anchored Proteins. | Biological and Pharmaceutical Bulletin | 2002 | 283 |
| 47 | Age-related macular degeneration and polypoidal choroidal vasculopathy in Asians | Progress in Retinal and Eye Research | 2016 | 276 |
| 48 | Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome | Clinical Cancer Research | 2003 | 275 |
| 49 | Structural Comparison of Fucosylated and Nonfucosylated Fc Fragments of Human Immunoglobulin G1 | Journal of Molecular Biology | 2007 | 273 |
| 50 | Hepatitis B Virus of Genotype B with or without Recombination with Genotype C over the Precore Region plus the Core Gene | Journal of Virology | 2002 | 270 |
