| # | Title | Journal | Year | Citations |
|---|
| 1 | ORTEP-3 for Windows - a version ofORTEP-III with a Graphical User Interface (GUI) | Journal of Applied Crystallography | 1997 | 19,266 |
| 2 | WinGXandORTEP for Windows: an update | Journal of Applied Crystallography | 2012 | 9,968 |
| 3 | Mutations of the BRAF gene in human cancer | Nature | 2002 | 9,374 |
| 4 | Observation of Gravitational Waves from a Binary Black Hole Merger | Physical Review Letters | 2016 | 8,753 |
| 5 | Statistical parametric maps in functional imaging: A general linear approach | Human Brain Mapping | 1994 | 8,177 |
| 6 | Signatures of mutational processes in human cancer | Nature | 2013 | 8,060 |
| 7 | Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia | New England Journal of Medicine | 1995 | 7,264 |
| 8 | VSEARCH: a versatile open source tool for metagenomics | PeerJ | 2016 | 7,113 |
| 9 | Random effects structure for confirmatory hypothesis testing: Keep it maximal | Journal of Memory and Language | 2013 | 6,772 |
| 10 | UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age | PLoS Medicine | 2015 | 6,753 |
| 11 | ASSESSMENT OF OUTCOME AFTER SEVERE BRAIN DAMAGE A Practical Scale | Lancet, The | 1975 | 6,557 |
| 12 | GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral | Physical Review Letters | 2017 | 6,413 |
| 13 | Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications | Biomaterials | 2005 | 5,951 |
| 14 | Nonparametric permutation tests for functional neuroimaging: A primer with examples | Human Brain Mapping | 2002 | 5,490 |
| 15 | Tree View: An application to display phylogenetic trees on personal computers | Bioinformatics | 1996 | 5,235 |
| 16 | ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC | European Heart Journal | 2012 | 5,233 |
| 17 | Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study | Lancet, The | 2012 | 4,855 |
| 18 | 2007 Guidelines for the Management of Arterial Hypertension | Journal of Hypertension | 2007 | 4,778 |
| 19 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 20 | Histological grading and staging of chronic hepatitis | Journal of Hepatology | 1995 | 4,685 |
| 21 | Twelve years of SAMtools and BCFtools | GigaScience | 2021 | 4,546 |
| 22 | Qualitative Research: Introducing focus groups | BMJ: British Medical Journal | 1995 | 4,272 |
| 23 | Early Identification of Refractory Epilepsy | New England Journal of Medicine | 2000 | 4,264 |
| 24 | 2013 ESH/ESC Guidelines for the management of arterial hypertension | Journal of Hypertension | 2013 | 4,251 |
| 25 | The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine | 2011 | 4,200 |
| 26 | Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction | New England Journal of Medicine | 2019 | 4,108 |
| 27 | Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science | Lancet Psychiatry,the | 2020 | 4,086 |
| 28 | Genetic studies of body mass index yield new insights for obesity biology | Nature | 2015 | 3,823 |
| 29 | Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies | Lancet, The | 2010 | 3,807 |
| 30 | The relation between load and penetration in the axisymmetric boussinesq problem for a punch of arbitrary profile | International Journal of Engineering Science | 1965 | 3,652 |
| 31 | Process evaluation of complex interventions: Medical Research Council guidance | BMJ, The | 2015 | 3,602 |
| 32 | Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial | Lancet, The | 2018 | 3,542 |
| 33 | The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP) | Radiocarbon | 2020 | 3,502 |
| 34 | Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial—Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial | Lancet, The | 2003 | 3,420 |
| 35 | EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update | Annals of the Rheumatic Diseases | 2017 | 3,366 |
| 36 | Biological, clinical and population relevance of 95 loci for blood lipids | Nature | 2010 | 3,249 |
| 37 | Review of Particle Physics | Progress of Theoretical and Experimental Physics | 2020 | 3,177 |
| 38 | Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial | Lancet, The | 2002 | 3,147 |
| 39 | Guidelines for the use and interpretation of assays for monitoring autophagy | Autophagy | 2012 | 3,122 |
| 40 | Widespread changes in protein synthesis induced by microRNAs | Nature | 2008 | 3,120 |
| 41 | Rheumatoid arthritis | Lancet, The | 2016 | 2,989 |
| 42 | Laser phase and frequency stabilization using an optical resonator | Applied Physics B, Photophysics and Laser Chemistry | 1983 | 2,973 |
| 43 | Formative assessment and self‐regulated learning: a model and seven principles of good feedback practice | Studies in Higher Education | 2006 | 2,916 |
| 44 | Crystal structure of an integral membrane light-harvesting complex from photosynthetic bacteria | Nature | 1995 | 2,743 |
| 45 | GW151226: Observation of Gravitational Waves from a 22-Solar-Mass Binary Black Hole Coalescence | Physical Review Letters | 2016 | 2,701 |
| 46 | Genomic analyses identify molecular subtypes of pancreatic cancer | Nature | 2016 | 2,700 |
| 47 | A DNA test to sex most birds | Molecular Ecology | 1998 | 2,688 |
| 48 | Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial | Lancet, The | 2005 | 2,662 |
| 49 | SARS-CoV-2 variants, spike mutations and immune escape | Nature Reviews Microbiology | 2021 | 2,650 |
| 50 | How to study proteins by circular dichroism | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2005 | 2,595 |
