| # | Title | Journal | Year | Citations |
|---|
| 1 | PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses | American Journal of Human Genetics | 2007 | 26,761 |
| 2 | Optical coherence tomography | Science | 1991 | 13,009 |
| 3 | The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 12,681 |
| 4 | The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary | Acta Neuropathologica | 2016 | 12,144 |
| 5 | Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging | Journal of the American Society of Echocardiography | 2015 | 10,755 |
| 6 | 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer | Thyroid | 2016 | 10,674 |
| 7 | Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib | New England Journal of Medicine | 2004 | 10,632 |
| 8 | An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest | NeuroImage | 2006 | 10,125 |
| 9 | The 2007 WHO Classification of Tumours of the Central Nervous System | Acta Neuropathologica | 2007 | 9,898 |
| 10 | Analysis of protein-coding genetic variation in 60,706 humans | Nature | 2016 | 9,051 |
| 11 | In vitro selection of RNA molecules that bind specific ligands | Nature | 1990 | 8,658 |
| 12 | Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Science | 1993 | 8,329 |
| 13 | Angiogenesis in cancer and other diseases | Nature | 2000 | 7,977 |
| 14 | The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia | Blood | 2016 | 7,429 |
| 15 | Whole Brain Segmentation | Neuron | 2002 | 7,404 |
| 16 | Acute Respiratory Distress Syndrome | JAMA - Journal of the American Medical Association | 2012 | 6,995 |
| 17 | Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines | Journal of Extracellular Vesicles | 2018 | 6,961 |
| 18 | The organization of the human cerebral cortex estimated by intrinsic functional connectivity | Journal of Neurophysiology | 2011 | 6,420 |
| 19 | Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Nature | 1993 | 6,331 |
| 20 | A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group [see comments] | Blood | 1994 | 6,150 |
| 21 | The mutational constraint spectrum quantified from variation in 141,456 humans | Nature | 2020 | 6,140 |
| 22 | Early Palliative Care for Patients with Metastatic Non–Small-Cell Lung Cancer | New England Journal of Medicine | 2010 | 6,066 |
| 23 | Guidelines for the Echocardiographic Assessment of the Right Heart in Adults: A Report from the American Society of Echocardiography | Journal of the American Society of Echocardiography | 2010 | 5,724 |
| 24 | Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee | Arthritis and Rheumatism | 1986 | 5,701 |
| 25 | Photodynamic therapy for cancer | Nature Reviews Cancer | 2003 | 5,585 |
| 26 | Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Alzheimer's and Dementia | 2011 | 5,550 |
| 27 | DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development | Cell | 1999 | 5,204 |
| 28 | 3D Slicer as an image computing platform for the Quantitative Imaging Network | Magnetic Resonance Imaging | 2012 | 5,126 |
| 29 | Measuring the thickness of the human cerebral cortex from magnetic resonance images | Proceedings of the National Academy of Sciences of the United States of America | 2000 | 4,968 |
| 30 | 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides | Arthritis and Rheumatism | 2013 | 4,839 |
| 31 | Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy | Science | 2005 | 4,792 |
| 32 | A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells | Cell | 2006 | 4,773 |
| 33 | Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) | Autophagy | 2016 | 4,701 |
| 34 | A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population | New England Journal of Medicine | 2009 | 4,673 |
| 35 | Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control | Science | 1981 | 4,621 |
| 36 | Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016 | Intensive Care Medicine | 2017 | 4,590 |
| 37 | The 2021 WHO Classification of Tumors of the Central Nervous System: a summary | Neuro-Oncology | 2021 | 4,534 |
| 38 | Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 | Journal of the American College of Cardiology | 2020 | 4,468 |
| 39 | Molecular mechanisms and clinical applications of angiogenesis | Nature | 2011 | 4,403 |
| 40 | Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients | Nature | 2014 | 4,342 |
| 41 | The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans | Nature | 2000 | 4,315 |
| 42 | Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers | Nature Cell Biology | 2008 | 4,285 |
| 43 | Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis | Nature Protocols | 2007 | 4,224 |
| 44 | Neuroinflammation in Alzheimer's disease | Lancet Neurology, The | 2015 | 4,129 |
| 45 | Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis | New England Journal of Medicine | 2001 | 4,090 |
| 46 | Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease | Nature | 2012 | 4,038 |
| 47 | Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 | Cell Death and Differentiation | 2018 | 4,036 |
| 48 | Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II | Arthritis and Rheumatism | 2008 | 4,029 |
| 49 | Tolerance of normal tissue to therapeutic irradiation | International Journal of Radiation Oncology Biology Physics | 1991 | 3,929 |
| 50 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration | Lancet Neurology, The | 2013 | 3,919 |
