| # | Title | Journal | Year | Citations |
|---|
| 1 | CD-Search: protein domain annotations on the fly | Nucleic Acids Research | 2004 | 1,785 |
| 2 | De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling | Nature | 2004 | 1,691 |
| 3 | The Revised Classification of Eukaryotes | Journal of Eukaryotic Microbiology | 2012 | 1,340 |
| 4 | Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems | Molecular Cell | 2015 | 971 |
| 5 | Iterated profile searches with PSI-BLAST—a tool for discovery in protein databases | Trends in Biochemical Sciences | 1998 | 674 |
| 6 | C-di-GMP: the dawning of a novel bacterial signalling system | Molecular Microbiology | 2005 | 593 |
| 7 | Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations | Nature Communications | 2011 | 481 |
| 8 | The HD domain defines a new superfamily of metal-dependent phosphohydrolases | Trends in Biochemical Sciences | 1998 | 432 |
| 9 | The domains of death: evolution of the apoptosis machinery | Trends in Biochemical Sciences | 1999 | 393 |
| 10 | START: a lipid-binding domain in StAR, HD-ZIP and signalling proteins | Trends in Biochemical Sciences | 1999 | 364 |
| 11 | Predicting functions from protein sequences—where are the bottlenecks? | Nature Genetics | 1998 | 306 |
| 12 | Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency | American Journal of Human Genetics | 2015 | 232 |
| 13 | Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome | Molecular Cell | 2019 | 183 |
| 14 | The genome sequence of the psychrophilic archaeon, Methanococcoides burtonii: the role of genome evolution in cold adaptation | ISME Journal | 2009 | 178 |
| 15 | Three major haplotypes of the β2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics | 2006 | 169 |
| 16 | Co-ordinated programme of gene expression during asexual intraerythrocytic development of the human malaria parasite Plasmodium falciparum revealed by microarray analysis | Molecular Microbiology | 2001 | 148 |
| 17 | Evaluation of query expansion using MeSH in PubMed | Information Retrieval | 2009 | 139 |
| 18 | Sex- and Tissue-Specific Functions of Drosophila Doublesex Transcription Factor Target Genes | Developmental Cell | 2014 | 122 |
| 19 | Systematic Nomenclature for GGDEF and EAL Domain-Containing Cyclic Di-GMP Turnover Proteins of Escherichia coli | Journal of Bacteriology | 2016 | 96 |
| 20 | Meeting report: GenBank microbial genomic taxonomy workshop (12–13 May, 2015) | Standards in Genomic Sciences | 2016 | 81 |
| 21 | WeSME: uncovering mutual exclusivity of cancer drivers and beyond | Bioinformatics | 2017 | 79 |
| 22 | Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics | Current Opinion in Microbiology | 2009 | 77 |
| 23 | Protein flexibility in the light of structural alphabets | Frontiers in Molecular Biosciences | 2015 | 71 |
| 24 | PAMP and PARL, two novel putative metalloproteases interacting with the COOH-terminus of Presenilin-1 and -2 | Journal of Alzheimer's Disease | 2001 | 61 |
| 25 | Structure and Regulation of the Mouse ing1 Gene | Journal of Biological Chemistry | 1999 | 60 |
| 26 | Self-regulated Cleavage of the Mitochondrial Intramembrane-cleaving Protease PARL Yields Pβ, a Nuclear-targeted Peptide | Journal of Biological Chemistry | 2004 | 60 |
| 27 | On the spread of epidemics in a closed heterogeneous population | Mathematical Biosciences | 2008 | 56 |
| 28 | COVID-19-CT-CXR: A Freely Accessible and Weakly Labeled Chest X-Ray and CT Image Collection on COVID-19 From Biomedical Literature | IEEE Transactions on Big Data | 2021 | 55 |
| 29 | The Shwachman-Bodian-Diamond syndrome gene encodes an RNA-binding protein that localizes to the pseudopod of Dictyostelium amoebae during chemotaxis | Journal of Cell Science | 2006 | 51 |
| 30 | Algorithms to Model Single Gene, Single Chromosome, and Whole Genome Copy Number Changes Jointly in Tumor Phylogenetics | PLoS Computational Biology | 2014 | 46 |
| 31 | P8008 The NCBI Eukaryotic Genome Annotation Pipeline | Journal of Animal Science | 2016 | 40 |
| 32 | On the need for an international effort to capture, share and use crystallization screening data | Acta Crystallographica Section F: Structural Biology Communications | 2012 | 38 |
| 33 | Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development | Cell Reports | 2018 | 38 |
| 34 | High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner | Journal of Biological Chemistry | 2013 | 37 |
| 35 | Assessment of penetrance and expressivity of RNAi‐mediated silencing of the Arabidopsis phytoene desaturase gene | New Phytologist | 2005 | 34 |
| 36 | Temporal Regulation of Gene Expression of the Thermus thermophilus Bacteriophage P23-45 | Journal of Molecular Biology | 2011 | 33 |
| 37 | The case for open science: rare diseases | JAMIA Open | 2020 | 33 |
| 38 | Molecular dissection of arginyltransferases guided by similarity to bacterial peptidoglycan synthases | EMBO Reports | 2006 | 30 |
| 39 | Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease | Cell Reports | 2017 | 28 |
| 40 | Sliding Motility, Biofilm Formation, and Glycopeptidolipid Production inMycobacterium colombienseStrains | BioMed Research International | 2015 | 27 |
| 41 | In silico identification and characterization of the ion transport specificity for P-type ATPases in the Mycobacterium tuberculosis complex | BMC Structural Biology | 2012 | 26 |
| 42 | Oxidative opening of the aromatic ring: Tracing the natural history of a large superfamily of dioxygenase domains and their relatives | Journal of Biological Chemistry | 2019 | 24 |
| 43 | Detecting sequence polymorphisms associated with meiotic recombination hotspots in the human genome | Genome Biology | 2010 | 23 |
| 44 | Searching for FLASH domains | Nature | 1999 | 20 |
| 45 | ChemSpider - building a foundation for the semantic web by hosting a crowd sourced databasing platform for chemistry | Journal of Cheminformatics | 2010 | 17 |
| 46 | BioSCAN: a VLSI-based system for biosequence analysis | | 0 | 16 |
| 47 | Databases of Discovery | Queue | 2005 | 14 |
| 48 | ‘Is Seeing Perceiving?’ Exploring issues concerning access to public transport for people with sight loss | British Journal of Visual Impairment | 2013 | 14 |
| 49 | Outlier detection in BLAST hits | Algorithms for Molecular Biology | 2018 | 14 |
| 50 | High-resolution genome-wide DNA methylation maps of mouse primary female dermal fibroblasts and keratinocytes | Epigenetics and Chromatin | 2014 | 12 |
