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Top Articles

#TitleJournalYearCitations
1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry1951284,654
2Protein measurement with the Folin phenol reagentJournal of Biological Chemistry1951242,821
3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry1976215,588
4A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry197692,750
5Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry198758,438
6A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry195755,906
7Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine200950,671
8The Sequence Alignment/Map format and SAMtoolsBioinformatics200949,124
9Fiji: an open-source platform for biological-image analysisNature Methods201247,818
10NIH Image to ImageJ: 25 years of image analysisNature Methods201246,756
11Trimmomatic: a flexible trimmer for Illumina sequence dataBioinformatics201446,646
12Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics200943,062
13Fast gapped-read alignment with Bowtie 2Nature Methods201242,357
14Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice TissuesCellular Physiology and Biochemistry201342,260
15A simple method for the isolation and purification of total lipides from animal tissuesJournal of Biological Chemistry195741,692
16A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195939,151
17STAR: ultrafast universal RNA-seq alignerBioinformatics201335,376
18edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataBioinformatics201032,955
19QIIME allows analysis of high-throughput community sequencing dataNature Methods201031,818
20Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry198727,111
21Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative UltracentrifugeClinical Chemistry197226,892
22Preparation of Graphitic OxideJournal of the American Chemical Society195826,827
23RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogeniesBioinformatics201426,744
24MrBayes 3: Bayesian phylogenetic inference under mixed modelsBioinformatics200326,519
25A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195925,451
26Clustal W and Clustal X version 2.0Bioinformatics200725,174
27A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry198324,572
28Adsorption of Gases in Multimolecular LayersJournal of the American Chemical Society193823,496
29A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology196123,305
30Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry197923,186
31Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics195923,177
32Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry197922,890
33clusterProfiler: an R Package for Comparing Biological Themes Among Gene ClustersOMICS A Journal of Integrative Biology201221,237
34BEDTools: a flexible suite of utilities for comparing genomic featuresBioinformatics201020,367
35A new generation of Ca2+ indicators with greatly improved fluorescence properties.Journal of Biological Chemistry198520,165
36MRBAYES: Bayesian inference of phylogenetic treesBioinformatics200120,154
37Measurement of protein using bicinchoninic acidAnalytical Biochemistry198519,774
38The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel ElectrophoresisJournal of Biological Chemistry196919,178
39SHELXT– Integrated space-group and crystal-structure determinationActa Crystallographica Section A: Foundations and Advances201518,933
40MODELTEST: testing the model of DNA substitutionBioinformatics199818,761
41DADA2: High-resolution sample inference from Illumina amplicon dataNature Methods201618,691
42Search and clustering orders of magnitude faster than BLASTBioinformatics201018,572
43THE ADSORPTION OF GASES ON PLANE SURFACES OF GLASS, MICA AND PLATINUM.Journal of the American Chemical Society191818,014
44Antioxidant activity applying an improved ABTS radical cation decolorization assayFree Radical Biology and Medicine199917,909
45Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic CellsJournal of the American Chemical Society200917,777
46High resolution two-dimensional electrophoresis of proteins.Journal of Biological Chemistry197517,755
47THE COLORIMETRIC DETERMINATION OF PHOSPHORUSJournal of Biological Chemistry192517,551
48SciPy 1.0: fundamental algorithms for scientific computing in PythonNature Methods202017,539
49WGCNA: an R package for weighted correlation network analysisBMC Bioinformatics200817,294
50HTSeq—a Python framework to work with high-throughput sequencing dataBioinformatics201517,270
51Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patchesPflugers Archiv European Journal of Physiology198117,126
52A modified single solution method for the determination of phosphate in natural watersAnalytica Chimica Acta196216,980
53featureCounts: an efficient general purpose program for assigning sequence reads to genomic featuresBioinformatics201416,839
54A new generation of Ca2+ indicators with greatly improved fluorescence propertiesJournal of Biological Chemistry198516,813
55The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresisJournal of Biological Chemistry196916,592
56HISAT: a fast spliced aligner with low memory requirementsNature Methods201516,262
57Geneious Basic: An integrated and extendable desktop software platform for the organization and analysis of sequence dataBioinformatics201216,096
58RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genomeBMC Bioinformatics201116,042
59The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP AssayAnalytical Biochemistry199616,000
60High resolution two-dimensional electrophoresis of proteinsJournal of Biological Chemistry197515,403
61BLAST+: architecture and applicationsBMC Bioinformatics200914,935
62RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed modelsBioinformatics200614,675
63Glutathione S-TransferasesJournal of Biological Chemistry197414,618
64NMRPipe: A multidimensional spectral processing system based on UNIX pipesJournal of Biomolecular NMR199514,090
65DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry194914,083
66Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical featuresBiopolymers198313,990
67Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry and Cytochemistry198113,859
68The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine200913,772
69DnaSP v5: a software for comprehensive analysis of DNA polymorphism dataBioinformatics200913,645
70jModelTest 2: more models, new heuristics and parallel computingNature Methods201213,416
71Development and use of quantum mechanical molecular models. 76. AM1: a new general purpose quantum mechanical molecular modelJournal of the American Chemical Society198513,340
72UCHIME improves sensitivity and speed of chimera detectionBioinformatics201113,241
73Pseudo-second order model for sorption processesProcess Biochemistry199913,223
74Haploview: analysis and visualization of LD and haplotype mapsBioinformatics200513,223
75UPARSE: highly accurate OTU sequences from microbial amplicon readsNature Methods201313,193
76Prokka: rapid prokaryotic genome annotationBioinformatics201412,881
77Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionBiochemical Pharmacology197312,583
78The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR ExperimentsClinical Chemistry200912,487
79Development and Testing of the OPLS All-Atom Force Field on Conformational Energetics and Properties of Organic LiquidsJournal of the American Chemical Society199612,123
80A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic MoleculesJournal of the American Chemical Society199512,116
81Phosphorus Assay in Column ChromatographyJournal of Biological Chemistry195912,077
82Mapping and quantifying mammalian transcriptomes by RNA-SeqNature Methods200812,050
83Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDaAnalytical Biochemistry198711,692
84The Determination of Enzyme Dissociation ConstantsJournal of the American Chemical Society193411,587
85FLASH: fast length adjustment of short reads to improve genome assembliesBioinformatics201111,573
86A method and server for predicting damaging missense mutationsNature Methods201011,491
87The Determination of Pore Volume and Area Distributions in Porous Substances. I. Computations from Nitrogen IsothermsJournal of the American Chemical Society195111,369
88Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortalScience Signaling201311,344
89The variant call format and VCFtoolsBioinformatics201111,326
90TopHat: discovering splice junctions with RNA-SeqBioinformatics200911,265
91Repertoires of Autophagy in the Pathogenesis of Ocular DiseasesCellular Physiology and Biochemistry201511,181
92Calcium's Role in Mechanotransduction during Muscle DevelopmentCellular Physiology and Biochemistry201411,109
93fastp: an ultra-fast all-in-one FASTQ preprocessorBioinformatics201811,005
94Superoxide DismutaseJournal of Biological Chemistry196910,959
95Glutathione S-transferases. The first enzymatic step in mercapturic acid formationJournal of Biological Chemistry197410,908
96Free radicals and antioxidants in normal physiological functions and human diseaseInternational Journal of Biochemistry and Cell Biology200710,891
97Analysis of nitrate, nitrite, and [15N]nitrate in biological fluidsAnalytical Biochemistry198210,819
98GenAlEx 6.5: genetic analysis in Excel. Population genetic software for teaching and research—an updateBioinformatics201210,741
99APE: Analyses of Phylogenetics and Evolution in R languageBioinformatics200410,601
100Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics researchBioinformatics200510,566