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Top Articles

#TitleJournalYearCitations
1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry1951284,654
2Protein measurement with the Folin phenol reagentJournal of Biological Chemistry1951242,821
3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry1976215,588
4A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry197692,750
5Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry198758,438
6Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Genome Biology201458,325
7A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue CulturesPhysiologia Plantarum196256,749
8A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry195755,906
9Hallmarks of Cancer: The Next GenerationCell201152,242
10Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine200950,671
11Fiji: an open-source platform for biological-image analysisNature Methods201247,818
12NIH Image to ImageJ: 25 years of image analysisNature Methods201246,756
13Fast gapped-read alignment with Bowtie 2Nature Methods201242,357
14A simple method for the isolation and purification of total lipides from animal tissuesJournal of Biological Chemistry195741,692
15MicroRNAsCell200432,446
16QIIME allows analysis of high-throughput community sequencing dataNature Methods201031,818
17Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry198727,111
18The Hallmarks of CancerCell200024,832
19THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPYJournal of Cell Biology196324,709
20A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry198324,572
21Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry197922,890
22Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell200622,649
23A new generation of Ca2+ indicators with greatly improved fluorescence properties.Journal of Biological Chemistry198520,165
24Measurement of protein using bicinchoninic acidAnalytical Biochemistry198519,774
25The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel ElectrophoresisJournal of Biological Chemistry196919,178
26Floral dip: a simplified method forAgrobacterium-mediated transformation ofArabidopsis thalianaPlant Journal199819,148
27DADA2: High-resolution sample inference from Illumina amplicon dataNature Methods201618,691
28Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell200717,969
29MicroRNAs: Target Recognition and Regulatory FunctionsCell200917,802
30High resolution two-dimensional electrophoresis of proteins.Journal of Biological Chemistry197517,755
31THE COLORIMETRIC DETERMINATION OF PHOSPHORUSJournal of Biological Chemistry192517,551
32SciPy 1.0: fundamental algorithms for scientific computing in PythonNature Methods202017,539
33A new generation of Ca2+ indicators with greatly improved fluorescence propertiesJournal of Biological Chemistry198516,813
34The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresisJournal of Biological Chemistry196916,592
35HISAT: a fast spliced aligner with low memory requirementsNature Methods201516,262
36SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease InhibitorCell202016,161
37The Ferric Reducing Ability of Plasma (FRAP) as a Measure of “Antioxidant Power”: The FRAP AssayAnalytical Biochemistry199616,000
38High resolution two-dimensional electrophoresis of proteinsJournal of Biological Chemistry197515,403
39Glutathione S-TransferasesJournal of Biological Chemistry197414,618
40DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry194914,083
41Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.Journal of Histochemistry and Cytochemistry198113,859
42Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statementCytotherapy200613,839
43The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine200913,772
44Differential expression analysis for sequence count dataGenome Biology201013,707
45jModelTest 2: more models, new heuristics and parallel computingNature Methods201213,416
46UPARSE: highly accurate OTU sequences from microbial amplicon readsNature Methods201313,193
47Phosphorus Assay in Column ChromatographyJournal of Biological Chemistry195912,077
48Mapping and quantifying mammalian transcriptomes by RNA-SeqNature Methods200812,050
49Matrix Elasticity Directs Stem Cell Lineage SpecificationCell200611,769
50Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDaAnalytical Biochemistry198711,692
51A series of normal stages in the development of the chick embryoJournal of Morphology195111,689
52A method and server for predicting damaging missense mutationsNature Methods201011,491
53Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortalScience Signaling201311,344
54The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell199311,149
55The Hallmarks of AgingCell201310,992
56Superoxide DismutaseJournal of Biological Chemistry196910,959
57Glutathione S-transferases. The first enzymatic step in mercapturic acid formationJournal of Biological Chemistry197410,908
58Free radicals and antioxidants in normal physiological functions and human diseaseInternational Journal of Biochemistry and Cell Biology200710,891
59Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA TargetsCell200510,880
60A genetic model for colorectal tumorigenesisCell199010,831
61Analysis of nitrate, nitrite, and [15N]nitrate in biological fluidsAnalytical Biochemistry198210,819
62Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature Cell Biology200710,558
63Superoxide dismutase: Improved assays and an assay applicable to acrylamide gelsAnalytical Biochemistry197110,405
64The Carbon Monoxide-binding Pigment of Liver MicrosomesJournal of Biological Chemistry196410,318
65Determination of serum proteins by means of the biuret reactionJournal of Biological Chemistry194910,253
66Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell IdentitiesMolecular Cell201010,215
67Apoptosis: A Review of Programmed Cell DeathToxicologic Pathology200710,063
68IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODSJournal of Cell Biology19619,922
69Phosphorus assay in column chromatographyJournal of Biological Chemistry19599,901
70Pathogen Recognition and Innate ImmunityCell20069,878
71Integrins: Versatility, modulation, and signaling in cell adhesionCell19929,858
72Comprehensive Integration of Single-Cell DataCell20199,755
73Mechanisms of Salinity ToleranceAnnual Review of Plant Biology20089,628
74ModelFinder: fast model selection for accurate phylogenetic estimatesNature Methods20179,486
75A simple technique for quantitation of low levels of DNA damage in individual cellsExperimental Cell Research19889,283
76REACTIVE OXYGEN SPECIES: Metabolism, Oxidative Stress, and Signal TransductionAnnual Review of Plant Biology20049,281
77Chromatin Modifications and Their FunctionCell20079,258
78A Film Detection Method for Tritium-Labelled Proteins and Nucleic Acids in Polyacrylamide GelsFEBS Journal19749,250
79Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.Molecular and Cellular Biology19829,217
80Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.Journal of Cell Biology19929,185
81A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSEJournal of Biological Chemistry19449,042
82Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell DeathCell20129,007
83THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATUREJournal of Biological Chemistry19648,804
84Fast and sensitive protein alignment using DIAMONDNature Methods20158,761
85“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein AAnalytical Biochemistry19818,736
86LIGAND: A versatile computerized approach for characterization of ligand-binding systemsAnalytical Biochemistry19808,732
87Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)Journal of Biological Chemistry19698,725
88Nutrient requirements of suspension cultures of soybean root cellsExperimental Cell Research19688,681
89Epithelial-Mesenchymal Transitions in Development and DiseaseCell20098,592
90A simplification of the protein assay method of Lowry et al. which is more generally applicableAnalytical Biochemistry19778,587
91SignalP 4.0: discriminating signal peptides from transmembrane regionsNature Methods20118,521
92Immunity, Inflammation, and CancerCell20108,516
93Robust enumeration of cell subsets from tissue expression profilesNature Methods20158,460
94Projections of Global Mortality and Burden of Disease from 2002 to 2030PLoS Medicine20068,440
95Enzymatic assembly of DNA molecules up to several hundred kilobasesNature Methods20098,117
96WAF1, a potential mediator of p53 tumor suppressionCell19938,091
97The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational StudiesPLoS Medicine20077,961
98A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomesCell19937,960
99Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide DismutaseFEBS Journal19747,903
100The Molecular Signatures Database Hallmark Gene Set CollectionCell Systems20157,719