# | Title | Journal | Year | Citations |
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1 | PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT | Journal of Biological Chemistry | 1951 | 284,654 |
2 | Protein measurement with the Folin phenol reagent | Journal of Biological Chemistry | 1951 | 242,821 |
3 | A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding | Analytical Biochemistry | 1976 | 215,588 |
4 | Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method | Methods | 2001 | 145,087 |
5 | A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding | Analytical Biochemistry | 1976 | 92,750 |
6 | Basic local alignment search tool | Journal of Molecular Biology | 1990 | 82,180 |
7 | A short history ofSHELX | Acta Crystallographica Section A: Foundations and Advances | 2008 | 81,966 |
8 | “Mini-mental state” | Journal of Psychiatric Research | 1975 | 77,621 |
9 | Gapped BLAST and PSI-BLAST: a new generation of protein database search programs | Nucleic Acids Research | 1997 | 64,420 |
10 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice | Nucleic Acids Research | 1994 | 59,168 |
11 | Long Short-Term Memory | Neural Computation | 1997 | 58,553 |
12 | Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction | Analytical Biochemistry | 1987 | 58,438 |
13 | Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 | Genome Biology | 2014 | 58,325 |
14 | A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue Cultures | Physiologia Plantarum | 1962 | 56,749 |
15 | A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES | Journal of Biological Chemistry | 1957 | 55,906 |
16 | The Measurement of Observer Agreement for Categorical Data | Biometrics | 1977 | 55,540 |
17 | Hallmarks of Cancer: The Next Generation | Cell | 2011 | 52,242 |
18 | Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement | PLoS Medicine | 2009 | 50,671 |
19 | The Sequence Alignment/Map format and SAMtools | Bioinformatics | 2009 | 49,124 |
20 | The neighbor-joining method: a new method for reconstructing phylogenetic trees. | Molecular Biology and Evolution | 1987 | 49,040 |
21 | Fiji: an open-source platform for biological-image analysis | Nature Methods | 2012 | 47,818 |
22 | Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays | Journal of Immunological Methods | 1983 | 47,133 |
23 | VMD: Visual molecular dynamics | Journal of Molecular Graphics | 1996 | 46,937 |
24 | NIH Image to ImageJ: 25 years of image analysis | Nature Methods | 2012 | 46,756 |
25 | Trimmomatic: a flexible trimmer for Illumina sequence data | Bioinformatics | 2014 | 46,646 |
26 | Fast and accurate short read alignment with Burrows–Wheeler transform | Bioinformatics | 2009 | 43,062 |
27 | Fast gapped-read alignment with Bowtie 2 | Nature Methods | 2012 | 42,357 |
28 | Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues | Cellular Physiology and Biochemistry | 2013 | 42,260 |
29 | A simple method for the isolation and purification of total lipides from animal tissues | Journal of Biological Chemistry | 1957 | 41,692 |
30 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 39,151 |
31 | G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences | Behavior Research Methods | 2007 | 38,307 |
32 | MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0 | Molecular Biology and Evolution | 2013 | 37,728 |
33 | Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks | Genome Research | 2003 | 37,062 |
34 | MUSCLE: multiple sequence alignment with high accuracy and high throughput | Nucleic Acids Research | 2004 | 36,947 |
35 | MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets | Molecular Biology and Evolution | 2016 | 36,708 |
36 | MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods | Molecular Biology and Evolution | 2011 | 36,550 |
37 | Detection of specific sequences among DNA fragments separated by gel electrophoresis | Journal of Molecular Biology | 1975 | 35,546 |
38 | STAR: ultrafast universal RNA-seq aligner | Bioinformatics | 2013 | 35,376 |
39 | CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP | Evolution; International Journal of Organic Evolution | 1985 | 35,356 |
40 | Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. | EMBO Journal | 1996 | 35,118 |
41 | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools | Nucleic Acids Research | 1997 | 34,934 |
42 | Gene Ontology: tool for the unification of biology | Nature Genetics | 2000 | 34,499 |
43 | Meta-analysis in clinical trials | Contemporary Clinical Trials | 1986 | 33,020 |
44 | edgeR: a Bioconductor package for differential expression analysis of digital gene expression data | Bioinformatics | 2010 | 32,955 |
45 | MicroRNAs | Cell | 2004 | 32,446 |
46 | The assessment and analysis of handedness: The Edinburgh inventory | Neuropsychologia | 1971 | 32,207 |
47 | MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability | Molecular Biology and Evolution | 2013 | 32,012 |
48 | Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources | Nature Protocols | 2009 | 31,831 |
49 | QIIME allows analysis of high-throughput community sequencing data | Nature Methods | 2010 | 31,818 |
50 | The Protein Data Bank | Nucleic Acids Research | 2000 | 31,087 |
51 | [20] Processing of X-ray diffraction data collected in oscillation mode | Methods in Enzymology | 1997 | 30,205 |
52 | A new mathematical model for relative quantification in real-time RT-PCR | Nucleic Acids Research | 2001 | 28,594 |
53 | Inference of Population Structure Using Multilocus Genotype Data | Genetics | 2000 | 28,015 |
54 | Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction | Analytical Biochemistry | 1987 | 27,111 |
55 | Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge | Clinical Chemistry | 1972 | 26,892 |
56 | Quantifying heterogeneity in a meta-analysis | Statistics in Medicine | 2002 | 26,845 |
57 | Preparation of Graphitic Oxide | Journal of the American Chemical Society | 1958 | 26,827 |
58 | PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses | American Journal of Human Genetics | 2007 | 26,761 |
59 | RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies | Bioinformatics | 2014 | 26,744 |
60 | Coot: model-building tools for molecular graphics | Acta Crystallographica Section D: Biological Crystallography | 2004 | 26,736 |
61 | MrBayes 3: Bayesian phylogenetic inference under mixed models | Bioinformatics | 2003 | 26,519 |
62 | limma powers differential expression analyses for RNA-sequencing and microarray studies | Nucleic Acids Research | 2015 | 26,032 |
63 | MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0 | Molecular Biology and Evolution | 2007 | 25,988 |
64 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences | Journal of Molecular Evolution | 1980 | 25,715 |
65 | MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms | Molecular Biology and Evolution | 2018 | 25,630 |
66 | A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION | Canadian Journal of Biochemistry and Physiology | 1959 | 25,451 |
67 | KEGG: Kyoto Encyclopedia of Genes and Genomes | Nucleic Acids Research | 2000 | 25,375 |
68 | Clustal W and Clustal X version 2.0 | Bioinformatics | 2007 | 25,174 |
69 | The Hallmarks of Cancer | Cell | 2000 | 24,832 |
70 | THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY | Journal of Cell Biology | 1963 | 24,709 |
71 | A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity | Analytical Biochemistry | 1983 | 24,572 |
72 | Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012 | International Journal of Cancer | 2015 | 23,615 |
73 | Adsorption of Gases in Multimolecular Layers | Journal of the American Chemical Society | 1938 | 23,496 |
74 | A new and rapid colorimetric determination of acetylcholinesterase activity | Biochemical Pharmacology | 1961 | 23,305 |
75 | The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research | Psychiatry Research | 1989 | 23,254 |
76 | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models | Behavior Research Methods | 2008 | 23,188 |
77 | Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease | Biochemistry | 1979 | 23,186 |
78 | Tissue sulfhydryl groups | Archives of Biochemistry and Biophysics | 1959 | 23,177 |
79 | Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction | Analytical Biochemistry | 1979 | 22,890 |
80 | Features and development of Coot | Acta Crystallographica Section D: Biological Crystallography | 2010 | 22,799 |
81 | Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors | Cell | 2006 | 22,649 |
82 | A simple method for displaying the hydropathic character of a protein | Journal of Molecular Biology | 1982 | 22,171 |
83 | OLEX2: a complete structure solution, refinement and analysis program | Journal of Applied Crystallography | 2009 | 21,944 |
84 | New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) | European Journal of Cancer | 2009 | 21,739 |
85 | The central role of the propensity score in observational studies for causal effects | Biometrika | 1983 | 21,591 |
86 | The SILVA ribosomal RNA gene database project: improved data processing and web-based tools | Nucleic Acids Research | 2012 | 21,425 |
87 | The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data | Genome Research | 2010 | 21,358 |
88 | clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters | OMICS A Journal of Integrative Biology | 2012 | 21,237 |
89 | PROCHECK: a program to check the stereochemical quality of protein structures | Journal of Applied Crystallography | 1993 | 21,188 |
90 | Analyzing real-time PCR data by the comparative CT method | Nature Protocols | 2008 | 21,086 |
91 | PHENIX: a comprehensive Python-based system for macromolecular structure solution | Acta Crystallographica Section D: Biological Crystallography | 2010 | 20,564 |
92 | MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model Space | Systematic Biology | 2012 | 20,458 |
93 | Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology | Genetics in Medicine | 2015 | 20,455 |
94 | THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS | Annals of the New York Academy of Sciences | 1949 | 20,417 |
95 | BEDTools: a flexible suite of utilities for comparing genomic features | Bioinformatics | 2010 | 20,367 |
96 | SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell Sequencing | Journal of Computational Biology | 2012 | 20,193 |
97 | A new generation of Ca2+ indicators with greatly improved fluorescence properties. | Journal of Biological Chemistry | 1985 | 20,165 |
98 | MRBAYES: Bayesian inference of phylogenetic trees | Bioinformatics | 2001 | 20,154 |
99 | Methods for Dietary Fiber, Neutral Detergent Fiber, and Nonstarch Polysaccharides in Relation to Animal Nutrition | Journal of Dairy Science | 1991 | 20,119 |
100 | The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errors | Molecular Physics | 1970 | 20,046 |