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Top Articles

#TitleJournalYearCitations
1Colorimetric Method for Determination of Sugars and Related SubstancesAnalytical Chemistry195643,792
2Use of Dinitrosalicylic Acid Reagent for Determination of Reducing SugarAnalytical Chemistry195922,304
3A modified single solution method for the determination of phosphate in natural watersAnalytica Chimica Acta196216,980
4Smoothing and Differentiation of Data by Simplified Least Squares Procedures.Analytical Chemistry196416,793
5Reaction Kinetics in Differential Thermal AnalysisAnalytical Chemistry195711,421
6SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modelingElectrophoresis199710,267
7Automatic Recording Apparatus for Use in Chromatography of Amino AcidsAnalytical Chemistry19589,702
8Sequential extraction procedure for the speciation of particulate trace metalsAnalytical Chemistry19799,583
9Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide GelsAnalytical Chemistry19968,535
10Official Methods of Analysis ofAnalytical Chemistry19808,357
11Probability-based protein identification by searching sequence databases using mass spectrometry dataElectrophoresis19997,555
12Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking AccuracyJournal of Medicinal Chemistry20047,428
13Microdetermination of PhosphorusAnalytical Chemistry19567,385
14PLS-regression: a basic tool of chemometricsChemometrics and Intelligent Laboratory Systems20017,224
15A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysJournal of Biomolecular Screening19996,128
16Partial least-squares regression: a tutorialAnalytica Chimica Acta19865,927
17An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein databaseJournal of the American Society for Mass Spectrometry19945,912
18The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicalsFood Chemistry19995,806
19Molecular Properties That Influence the Oral Bioavailability of Drug CandidatesJournal of Medicinal Chemistry20025,626
20Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltonsAnalytical Chemistry19885,240
21Extra Precision Glide:  Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand ComplexesJournal of Medicinal Chemistry20065,196
22A generalization of the retention index system including linear temperature programmed gas—liquid partition chromatographyJournal of Chromatography A19635,042
23Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression ProteomicsMolecular and Cellular Proteomics20024,931
24THREE NATURAL ZIRCON STANDARDS FOR U-TH-PB, LU-HF, TRACE ELEMENT AND REE ANALYSESGeostandards and Geoanalytical Research19954,868
25Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane)Analytical Chemistry19984,788
26Theory of Stationary Electrode Polarography. Single Scan and Cyclic Methods Applied to Reversible, Irreversible, and Kinetic Systems.Analytical Chemistry19644,783
27Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MSAnalytical Chemistry20034,530
28Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database SearchAnalytical Chemistry20024,503
29Natural Products as Sources of New Drugs from 1981 to 2014Journal of Natural Products20164,486
30Solid phase microextraction with thermal desorption using fused silica optical fibersAnalytical Chemistry19904,432
31Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in ProduceJournal of AOAC INTERNATIONAL20034,413
32A Statistical Model for Identifying Proteins by Tandem Mass SpectrometryAnalytical Chemistry20034,283
33Response surface methodology (RSM) as a tool for optimization in analytical chemistryTalanta20084,224
34Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQMolecular and Cellular Proteomics20144,178
35XCMS:  Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and IdentificationAnalytical Chemistry20064,128
36Ferrozine---a new spectrophotometric reagent for ironAnalytical Chemistry19704,034
37Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved PharmaceuticalsJournal of Medicinal Chemistry20143,996
38Glide:  A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database ScreeningJournal of Medicinal Chemistry20043,982
39Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010Journal of Natural Products20123,976
40Limits for qualitative detection and quantitative determination. Application to radiochemistryAnalytical Chemistry19683,937
41Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gelsElectrophoresis19873,913
42Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging ReagentsMolecular and Cellular Proteomics20043,873
43Natural Products as Sources of New Drugs over the Last 25 Years⊥Journal of Natural Products20073,838
44The Human Plasma ProteomeMolecular and Cellular Proteomics20023,776
45Flavonoids as AntioxidantsJournal of Natural Products20003,737
46Methods for in vitro evaluating antimicrobial activity: A reviewJournal of Pharmaceutical Analysis20163,675
47A simple and rapid method for the permethylation of carbohydratesCarbohydrate Research19843,436
48Phenol-hypochlorite reaction for determination of ammoniaAnalytical Chemistry19673,346
49Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019Journal of Natural Products20203,162
50Brine Shrimp: A Convenient General Bioassay for Active Plant ConstituentsPlanta Medica19823,136
51Fabrication of microfluidic systems in poly(dimethylsiloxane)Electrophoresis20003,078
52Determination of organic compounds in water using dispersive liquid–liquid microextractionJournal of Chromatography A20063,021
53Determination of Size and Concentration of Gold Nanoparticles from UV−Vis SpectraAnalytical Chemistry20073,008
54The Many Roles for Fluorine in Medicinal ChemistryJournal of Medicinal Chemistry20082,993
55New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in BioassaysJournal of Medicinal Chemistry20102,982
56Arsenic round the world: a reviewTalanta20022,969
57Theory and Application of Cyclic Voltammetry for Measurement of Electrode Reaction Kinetics.Analytical Chemistry19652,930
58Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programsTalanta19962,888
59Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometryRapid Communications in Mass Spectrometry19882,854
60Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based ProteomicsMolecular and Cellular Proteomics20142,819
61Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical SuccessJournal of Medicinal Chemistry20092,807
62Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer PropertiesMolecules20102,795
63Graphene Based Electrochemical Sensors and Biosensors: A ReviewElectroanalysis20102,779
64Surface-Enhanced Raman SpectroscopyAnnual Review of Analytical Chemistry20082,684
65Determination of the equivalence point in potentiometric titrations. Part IIAnalyst, The19522,650
66Preparation and Characterization of Au Colloid MonolayersAnalytical Chemistry19952,637
67Iolite: Freeware for the visualisation and processing of mass spectrometric dataJournal of Analytical Atomic Spectrometry20112,629
68How to study proteins by circular dichroismBiochimica Et Biophysica Acta - Proteins and Proteomics20052,595
69A computational procedure for determining energetically favorable binding sites on biologically important macromoleculesJournal of Medicinal Chemistry19852,586
70Electrochemical technologies in wastewater treatmentSeparation and Purification Technology20042,585
71Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250Electrophoresis19882,534
72Applications of Fluorine in Medicinal ChemistryJournal of Medicinal Chemistry20152,464
73Letter to the editorsBiomedical Mass Spectrometry19842,433
74Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport PropertiesJournal of Medicinal Chemistry20002,413
75Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products20032,412
76In vivo near-infrared fluorescence imagingCurrent Opinion in Chemical Biology20032,397
77Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative informationAnalytical Chemistry19882,378
78Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in ProteomicsAnalytical Chemistry20032,337
79pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based SignaturesJournal of Medicinal Chemistry20152,335
80PARAFAC. Tutorial and applicationsChemometrics and Intelligent Laboratory Systems19972,318
81Partial least squares for discriminationJournal of Chemometrics20032,296
82Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential usesFood Chemistry20062,285
83Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome AnalysisMolecular and Cellular Proteomics20122,285
84A Compilation of New and Published Major and Trace Element Data for NIST SRM 610 and NIST SRM 612 Glass Reference MaterialsGeostandards and Geoanalytical Research19972,280
85A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun ProteomicsAnalytical Chemistry20042,280
86Electrolysis of water on oxide surfacesJournal of Electroanalytical Chemistry20072,277
87Diagnostics for the Developing World: Microfluidic Paper-Based Analytical DevicesAnalytical Chemistry20102,268
88Box-Behnken design: An alternative for the optimization of analytical methodsAnalytica Chimica Acta20072,226
89Synopsis of Some Recent Tactical Application of Bioisosteres in Drug DesignJournal of Medicinal Chemistry20112,216
90Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic DevicesAnalytical Chemistry20032,206
91Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient ConditionsAnalytical Chemistry20052,200
92Carbon-Nanotube Based Electrochemical Biosensors: A ReviewElectroanalysis20052,181
93Zone electrophoresis in open-tubular glass capillariesAnalytical Chemistry19812,177
94Metal Oxide Gas Sensors: Sensitivity and Influencing FactorsSensors20102,177
95High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy NumberAnalytical Chemistry20112,175
96Chromatography of Amino Acids on Sulfonated Polystyrene Resins. An Improved SystemAnalytical Chemistry19582,132
97The determination of amino-acids with ninhydrinAnalyst, The19552,126
98Micro Total Analysis Systems. 1. Introduction, Theory, and TechnologyAnalytical Chemistry20022,122
99Rapid Preparation of Fatty Acid Esters from Lipids for Gas Chromatographic Analysis.Analytical Chemistry19662,113
100Difference gel electrophoresis. A single gel method for detecting changes in protein extractsElectrophoresis19972,104