# | Title | Journal | Year | Citations |
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1 | Colorimetric Method for Determination of Sugars and Related Substances | Analytical Chemistry | 1956 | 43,792 |
2 | Use of Dinitrosalicylic Acid Reagent for Determination of Reducing Sugar | Analytical Chemistry | 1959 | 22,304 |
3 | A modified single solution method for the determination of phosphate in natural waters | Analytica Chimica Acta | 1962 | 16,980 |
4 | Smoothing and Differentiation of Data by Simplified Least Squares Procedures. | Analytical Chemistry | 1964 | 16,793 |
5 | Reaction Kinetics in Differential Thermal Analysis | Analytical Chemistry | 1957 | 11,421 |
6 | SWISS-MODEL and the Swiss-Pdb Viewer: An environment for comparative protein modeling | Electrophoresis | 1997 | 10,267 |
7 | Automatic Recording Apparatus for Use in Chromatography of Amino Acids | Analytical Chemistry | 1958 | 9,702 |
8 | Sequential extraction procedure for the speciation of particulate trace metals | Analytical Chemistry | 1979 | 9,583 |
9 | Mass Spectrometric Sequencing of Proteins from Silver-Stained Polyacrylamide Gels | Analytical Chemistry | 1996 | 8,535 |
10 | Official Methods of Analysis of | Analytical Chemistry | 1980 | 8,357 |
11 | Probability-based protein identification by searching sequence databases using mass spectrometry data | Electrophoresis | 1999 | 7,555 |
12 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy | Journal of Medicinal Chemistry | 2004 | 7,428 |
13 | Microdetermination of Phosphorus | Analytical Chemistry | 1956 | 7,385 |
14 | PLS-regression: a basic tool of chemometrics | Chemometrics and Intelligent Laboratory Systems | 2001 | 7,224 |
15 | A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays | Journal of Biomolecular Screening | 1999 | 6,128 |
16 | Partial least-squares regression: a tutorial | Analytica Chimica Acta | 1986 | 5,927 |
17 | An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database | Journal of the American Society for Mass Spectrometry | 1994 | 5,912 |
18 | The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals | Food Chemistry | 1999 | 5,806 |
19 | Molecular Properties That Influence the Oral Bioavailability of Drug Candidates | Journal of Medicinal Chemistry | 2002 | 5,626 |
20 | Laser desorption ionization of proteins with molecular masses exceeding 10,000 daltons | Analytical Chemistry | 1988 | 5,240 |
21 | Extra Precision Glide: Docking and Scoring Incorporating a Model of Hydrophobic Enclosure for Protein−Ligand Complexes | Journal of Medicinal Chemistry | 2006 | 5,196 |
22 | A generalization of the retention index system including linear temperature programmed gas—liquid partition chromatography | Journal of Chromatography A | 1963 | 5,042 |
23 | Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics | Molecular and Cellular Proteomics | 2002 | 4,931 |
24 | THREE NATURAL ZIRCON STANDARDS FOR U-TH-PB, LU-HF, TRACE ELEMENT AND REE ANALYSES | Geostandards and Geoanalytical Research | 1995 | 4,868 |
25 | Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane) | Analytical Chemistry | 1998 | 4,788 |
26 | Theory of Stationary Electrode Polarography. Single Scan and Cyclic Methods Applied to Reversible, Irreversible, and Kinetic Systems. | Analytical Chemistry | 1964 | 4,783 |
27 | Strategies for the Assessment of Matrix Effect in Quantitative Bioanalytical Methods Based on HPLC−MS/MS | Analytical Chemistry | 2003 | 4,530 |
28 | Empirical Statistical Model To Estimate the Accuracy of Peptide Identifications Made by MS/MS and Database Search | Analytical Chemistry | 2002 | 4,503 |
29 | Natural Products as Sources of New Drugs from 1981 to 2014 | Journal of Natural Products | 2016 | 4,486 |
30 | Solid phase microextraction with thermal desorption using fused silica optical fibers | Analytical Chemistry | 1990 | 4,432 |
31 | Fast and Easy Multiresidue Method Employing Acetonitrile Extraction/Partitioning and “Dispersive Solid-Phase Extraction” for the Determination of Pesticide Residues in Produce | Journal of AOAC INTERNATIONAL | 2003 | 4,413 |
32 | A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry | Analytical Chemistry | 2003 | 4,283 |
33 | Response surface methodology (RSM) as a tool for optimization in analytical chemistry | Talanta | 2008 | 4,224 |
34 | Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ | Molecular and Cellular Proteomics | 2014 | 4,178 |
35 | XCMS: Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification | Analytical Chemistry | 2006 | 4,128 |
36 | Ferrozine---a new spectrophotometric reagent for iron | Analytical Chemistry | 1970 | 4,034 |
37 | Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals | Journal of Medicinal Chemistry | 2014 | 3,996 |
38 | Glide: A New Approach for Rapid, Accurate Docking and Scoring. 2. Enrichment Factors in Database Screening | Journal of Medicinal Chemistry | 2004 | 3,982 |
39 | Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010 | Journal of Natural Products | 2012 | 3,976 |
40 | Limits for qualitative detection and quantitative determination. Application to radiochemistry | Analytical Chemistry | 1968 | 3,937 |
41 | Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels | Electrophoresis | 1987 | 3,913 |
42 | Multiplexed Protein Quantitation in Saccharomyces cerevisiae Using Amine-reactive Isobaric Tagging Reagents | Molecular and Cellular Proteomics | 2004 | 3,873 |
43 | Natural Products as Sources of New Drugs over the Last 25 Years⊥ | Journal of Natural Products | 2007 | 3,838 |
44 | The Human Plasma Proteome | Molecular and Cellular Proteomics | 2002 | 3,776 |
45 | Flavonoids as Antioxidants | Journal of Natural Products | 2000 | 3,737 |
46 | Methods for in vitro evaluating antimicrobial activity: A review | Journal of Pharmaceutical Analysis | 2016 | 3,675 |
47 | A simple and rapid method for the permethylation of carbohydrates | Carbohydrate Research | 1984 | 3,436 |
48 | Phenol-hypochlorite reaction for determination of ammonia | Analytical Chemistry | 1967 | 3,346 |
49 | Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 | Journal of Natural Products | 2020 | 3,162 |
50 | Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents | Planta Medica | 1982 | 3,136 |
51 | Fabrication of microfluidic systems in poly(dimethylsiloxane) | Electrophoresis | 2000 | 3,078 |
52 | Determination of organic compounds in water using dispersive liquid–liquid microextraction | Journal of Chromatography A | 2006 | 3,021 |
53 | Determination of Size and Concentration of Gold Nanoparticles from UV−Vis Spectra | Analytical Chemistry | 2007 | 3,008 |
54 | The Many Roles for Fluorine in Medicinal Chemistry | Journal of Medicinal Chemistry | 2008 | 2,993 |
55 | New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry | 2010 | 2,982 |
56 | Arsenic round the world: a review | Talanta | 2002 | 2,969 |
57 | Theory and Application of Cyclic Voltammetry for Measurement of Electrode Reaction Kinetics. | Analytical Chemistry | 1965 | 2,930 |
58 | Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs | Talanta | 1996 | 2,888 |
59 | Protein and polymer analyses up tom/z 100 000 by laser ionization time-of-flight mass spectrometry | Rapid Communications in Mass Spectrometry | 1988 | 2,854 |
60 | Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics | Molecular and Cellular Proteomics | 2014 | 2,819 |
61 | Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success | Journal of Medicinal Chemistry | 2009 | 2,807 |
62 | Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties | Molecules | 2010 | 2,795 |
63 | Graphene Based Electrochemical Sensors and Biosensors: A Review | Electroanalysis | 2010 | 2,779 |
64 | Surface-Enhanced Raman Spectroscopy | Annual Review of Analytical Chemistry | 2008 | 2,684 |
65 | Determination of the equivalence point in potentiometric titrations. Part II | Analyst, The | 1952 | 2,650 |
66 | Preparation and Characterization of Au Colloid Monolayers | Analytical Chemistry | 1995 | 2,637 |
67 | Iolite: Freeware for the visualisation and processing of mass spectrometric data | Journal of Analytical Atomic Spectrometry | 2011 | 2,629 |
68 | How to study proteins by circular dichroism | Biochimica Et Biophysica Acta - Proteins and Proteomics | 2005 | 2,595 |
69 | A computational procedure for determining energetically favorable binding sites on biologically important macromolecules | Journal of Medicinal Chemistry | 1985 | 2,586 |
70 | Electrochemical technologies in wastewater treatment | Separation and Purification Technology | 2004 | 2,585 |
71 | Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250 | Electrophoresis | 1988 | 2,534 |
72 | Applications of Fluorine in Medicinal Chemistry | Journal of Medicinal Chemistry | 2015 | 2,464 |
73 | Letter to the editors | Biomedical Mass Spectrometry | 1984 | 2,433 |
74 | Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties | Journal of Medicinal Chemistry | 2000 | 2,413 |
75 | Natural Products as Sources of New Drugs over the Period 1981−2002 | Journal of Natural Products | 2003 | 2,412 |
76 | In vivo near-infrared fluorescence imaging | Current Opinion in Chemical Biology | 2003 | 2,397 |
77 | Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative information | Analytical Chemistry | 1988 | 2,378 |
78 | Stop and Go Extraction Tips for Matrix-Assisted Laser Desorption/Ionization, Nanoelectrospray, and LC/MS Sample Pretreatment in Proteomics | Analytical Chemistry | 2003 | 2,337 |
79 | pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures | Journal of Medicinal Chemistry | 2015 | 2,335 |
80 | PARAFAC. Tutorial and applications | Chemometrics and Intelligent Laboratory Systems | 1997 | 2,318 |
81 | Partial least squares for discrimination | Journal of Chemometrics | 2003 | 2,296 |
82 | Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses | Food Chemistry | 2006 | 2,285 |
83 | Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis | Molecular and Cellular Proteomics | 2012 | 2,285 |
84 | A Compilation of New and Published Major and Trace Element Data for NIST SRM 610 and NIST SRM 612 Glass Reference Materials | Geostandards and Geoanalytical Research | 1997 | 2,280 |
85 | A Model for Random Sampling and Estimation of Relative Protein Abundance in Shotgun Proteomics | Analytical Chemistry | 2004 | 2,280 |
86 | Electrolysis of water on oxide surfaces | Journal of Electroanalytical Chemistry | 2007 | 2,277 |
87 | Diagnostics for the Developing World: Microfluidic Paper-Based Analytical Devices | Analytical Chemistry | 2010 | 2,268 |
88 | Box-Behnken design: An alternative for the optimization of analytical methods | Analytica Chimica Acta | 2007 | 2,226 |
89 | Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design | Journal of Medicinal Chemistry | 2011 | 2,216 |
90 | Solvent Compatibility of Poly(dimethylsiloxane)-Based Microfluidic Devices | Analytical Chemistry | 2003 | 2,206 |
91 | Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions | Analytical Chemistry | 2005 | 2,200 |
92 | Carbon-Nanotube Based Electrochemical Biosensors: A Review | Electroanalysis | 2005 | 2,181 |
93 | Zone electrophoresis in open-tubular glass capillaries | Analytical Chemistry | 1981 | 2,177 |
94 | Metal Oxide Gas Sensors: Sensitivity and Influencing Factors | Sensors | 2010 | 2,177 |
95 | High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number | Analytical Chemistry | 2011 | 2,175 |
96 | Chromatography of Amino Acids on Sulfonated Polystyrene Resins. An Improved System | Analytical Chemistry | 1958 | 2,132 |
97 | The determination of amino-acids with ninhydrin | Analyst, The | 1955 | 2,126 |
98 | Micro Total Analysis Systems. 1. Introduction, Theory, and Technology | Analytical Chemistry | 2002 | 2,122 |
99 | Rapid Preparation of Fatty Acid Esters from Lipids for Gas Chromatographic Analysis. | Analytical Chemistry | 1966 | 2,113 |
100 | Difference gel electrophoresis. A single gel method for detecting changes in protein extracts | Electrophoresis | 1997 | 2,104 |