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Top Articles

#TitleJournalYearCitations
1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry1951284,654
2Protein measurement with the Folin phenol reagentJournal of Biological Chemistry1951242,821
3A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingAnalytical Biochemistry1976215,588
4Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods2001145,087
5A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye BindingAnalytical Biochemistry197692,750
6Basic local alignment search toolJournal of Molecular Biology199082,180
7A short history ofSHELXActa Crystallographica Section A: Foundations and Advances200881,966
8Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research199764,420
9CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research199459,168
10Long Short-Term MemoryNeural Computation199758,553
11Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extractionAnalytical Biochemistry198758,438
12Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2Genome Biology201458,325
13A Revised Medium for Rapid Growth and Bio Assays with Tobacco Tissue CulturesPhysiologia Plantarum196256,749
14A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUESJournal of Biological Chemistry195755,906
15Hallmarks of Cancer: The Next GenerationCell201152,242
16Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA StatementPLoS Medicine200950,671
17The Sequence Alignment/Map format and SAMtoolsBioinformatics200949,124
18The neighbor-joining method: a new method for reconstructing phylogenetic trees.Molecular Biology and Evolution198749,040
19Fiji: an open-source platform for biological-image analysisNature Methods201247,818
20Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysJournal of Immunological Methods198347,133
21NIH Image to ImageJ: 25 years of image analysisNature Methods201246,756
22Trimmomatic: a flexible trimmer for Illumina sequence dataBioinformatics201446,646
23Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics200943,062
24Fast gapped-read alignment with Bowtie 2Nature Methods201242,357
25Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice TissuesCellular Physiology and Biochemistry201342,260
26A simple method for the isolation and purification of total lipides from animal tissuesJournal of Biological Chemistry195741,692
27A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195939,151
28MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0Molecular Biology and Evolution201337,728
29Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research200337,062
30MUSCLE: multiple sequence alignment with high accuracy and high throughputNucleic Acids Research200436,947
31MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger DatasetsMolecular Biology and Evolution201636,708
32MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony MethodsMolecular Biology and Evolution201136,550
33Detection of specific sequences among DNA fragments separated by gel electrophoresisJournal of Molecular Biology197535,546
34STAR: ultrafast universal RNA-seq alignerBioinformatics201335,376
35CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAPEvolution; International Journal of Organic Evolution198535,356
36Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.EMBO Journal199635,118
37The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis toolsNucleic Acids Research199734,934
38Gene Ontology: tool for the unification of biologyNature Genetics200034,499
39edgeR: a Bioconductor package for differential expression analysis of digital gene expression dataBioinformatics201032,955
40MicroRNAsCell200432,446
41The assessment and analysis of handedness: The Edinburgh inventoryNeuropsychologia197132,207
42MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and UsabilityMolecular Biology and Evolution201332,012
43QIIME allows analysis of high-throughput community sequencing dataNature Methods201031,818
44The Protein Data BankNucleic Acids Research200031,087
45A new mathematical model for relative quantification in real-time RT-PCRNucleic Acids Research200128,594
46Inference of Population Structure Using Multilocus Genotype DataGenetics200028,015
47Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionAnalytical Biochemistry198727,111
48Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative UltracentrifugeClinical Chemistry197226,892
49Quantifying heterogeneity in a meta-analysisStatistics in Medicine200226,845
50Preparation of Graphitic OxideJournal of the American Chemical Society195826,827
51PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics200726,761
52RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogeniesBioinformatics201426,744
53MrBayes 3: Bayesian phylogenetic inference under mixed modelsBioinformatics200326,519
54limma powers differential expression analyses for RNA-sequencing and microarray studiesNucleic Acids Research201526,032
55MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0Molecular Biology and Evolution200725,988
56A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequencesJournal of Molecular Evolution198025,715
57MEGA X: Molecular Evolutionary Genetics Analysis across Computing PlatformsMolecular Biology and Evolution201825,630
58A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology195925,451
59KEGG: Kyoto Encyclopedia of Genes and GenomesNucleic Acids Research200025,375
60Clustal W and Clustal X version 2.0Bioinformatics200725,174
61The Hallmarks of CancerCell200024,832
62THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPYJournal of Cell Biology196324,709
63A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry198324,572
64Adsorption of Gases in Multimolecular LayersJournal of the American Chemical Society193823,496
65A new and rapid colorimetric determination of acetylcholinesterase activityBiochemical Pharmacology196123,305
66Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry197923,186
67Tissue sulfhydryl groupsArchives of Biochemistry and Biophysics195923,177
68Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionAnalytical Biochemistry197922,890
69Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined FactorsCell200622,649
70A simple method for displaying the hydropathic character of a proteinJournal of Molecular Biology198222,171
71The SILVA ribosomal RNA gene database project: improved data processing and web-based toolsNucleic Acids Research201221,425
72The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing dataGenome Research201021,358
73clusterProfiler: an R Package for Comparing Biological Themes Among Gene ClustersOMICS A Journal of Integrative Biology201221,237
74MrBayes 3.2: Efficient Bayesian Phylogenetic Inference and Model Choice Across a Large Model SpaceSystematic Biology201220,458
75Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular PathologyGenetics in Medicine201520,455
76BEDTools: a flexible suite of utilities for comparing genomic featuresBioinformatics201020,367
77SPAdes: A New Genome Assembly Algorithm and Its Applications to Single-Cell SequencingJournal of Computational Biology201220,193
78A new generation of Ca2+ indicators with greatly improved fluorescence properties.Journal of Biological Chemistry198520,165
79MRBAYES: Bayesian inference of phylogenetic treesBioinformatics200120,154
80Methods for Dietary Fiber, Neutral Detergent Fiber, and Nonstarch Polysaccharides in Relation to Animal NutritionJournal of Dairy Science199120,119
81The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errorsMolecular Physics197020,046
82Measurement of protein using bicinchoninic acidAnalytical Biochemistry198519,774
83COPPER ENZYMES IN ISOLATED CHLOROPLASTS. POLYPHENOLOXIDASE IN BETA VULGARISPlant Physiology194919,369
84The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel ElectrophoresisJournal of Biological Chemistry196919,178
85Floral dip: a simplified method forAgrobacterium-mediated transformation ofArabidopsis thalianaPlant Journal199819,148
86SHELXT– Integrated space-group and crystal-structure determinationActa Crystallographica Section A: Foundations and Advances201518,933
87A quantitative description of membrane current and its application to conduction and excitation in nerveJournal of Physiology195218,877
88MODELTEST: testing the model of DNA substitutionBioinformatics199818,761
89DADA2: High-resolution sample inference from Illumina amplicon dataNature Methods201618,691
90Search and clustering orders of magnitude faster than BLASTBioinformatics201018,572
91Detecting the number of clusters of individuals using the software structure: a simulation studyMolecular Ecology200518,555
92Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial CommunitiesApplied and Environmental Microbiology200918,390
93The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis and Rheumatism198818,339
94EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysisJournal of Neuroscience Methods200418,121
95THE ADSORPTION OF GASES ON PLANE SURFACES OF GLASS, MICA AND PLATINUM.Journal of the American Chemical Society191818,014
96Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined FactorsCell200717,969
97Antioxidant activity applying an improved ABTS radical cation decolorization assayFree Radical Biology and Medicine199917,909
98MicroRNAs: Target Recognition and Regulatory FunctionsCell200917,802
99Organometal Halide Perovskites as Visible-Light Sensitizers for Photovoltaic CellsJournal of the American Chemical Society200917,777
100High resolution two-dimensional electrophoresis of proteins.Journal of Biological Chemistry197517,755